Bcl-2 and Bax expressions in pre-term, term and post-term placentas

Bcl-2 and Bax expressions in pre-term, term and post-term placentas

Autor Daher, Silvia Autor UNIFESP Google Scholar
Guimaraes, Alberto Jorge de Sousa Autor UNIFESP Google Scholar
Mattar, Rosiane Autor UNIFESP Google Scholar
Ishigai, Marcia Marcelino de Souza Autor UNIFESP Google Scholar
Barreiro, Erica Giovana Autor UNIFESP Google Scholar
Bevilacqua, Estela Maris Andrade Forell Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo ProblemPlacental apoptosis-associated protein imbalance might contribute to the pathogenesis of pre- and post-term birth. Therefore, we evaluated the expression and distribution of pro-apoptotic (Bax) and anti-apoptotic (Bcl-2) molecules in term, pre-term and post-term placentas.Method of StudyPlacental samples were collected from women with term (n = 25), pre-term (n = 7) and post-term (n = 10) deliveries. the expression of Bcl-2 and Bax was assessed by immunochemistry on paraffin-embedded placental specimens.ResultsThe pattern of immunostaining for Bcl-2 and Bax was the same in all samples, but not the intensity. the Bax/Bcl-2 ratio was higher in both pre-term and post-term placental samples compared with term placentas as a result of intense reactivity for the pro-apoptotic factor, Bax in pre-term and post-term placentas and, for Bcl-2 decrease in pre-term placentas.ConclusionThese findings suggest that different unbalance mechanisms in placental apoptotic-associated protein expressions may be involved in the physiopathology of pre-term and post-term births.
Palavra-chave apoptosis
parturition
placenta
post-term birth
premature labor
Idioma Inglês
Data de publicação 2008-08-01
Publicado em American Journal of Reproductive Immunology. Malden: Wiley-Blackwell, v. 60, n. 2, p. 172-178, 2008.
ISSN 1046-7408 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 172-178
Fonte http://dx.doi.org/10.1111/j.1600-0897.2008.00609.x
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000257513800009
Endereço permanente http://repositorio.unifesp.br/handle/11600/30839

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