Effects of corticosteroid therapy on the long-term outcome of radiofrequency lesions in the swine caval veins

Effects of corticosteroid therapy on the long-term outcome of radiofrequency lesions in the swine caval veins

Autor Fenelon, Guilherme Autor UNIFESP Google Scholar
Nascimento, Thais Autor UNIFESP Google Scholar
De Araujo, Sergio Autor UNIFESP Google Scholar
Okada, Mieko Autor UNIFESP Google Scholar
Franco, Marcello Autor UNIFESP Google Scholar
De Paola, Angelo A. V. Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Background: We explored the angiographic and pathological effects of corticosteroids on the long-term outcome of radiofrequency (RF) ablation lesions in the swine caval veins.Methods: Under fluoroscopy guidance, a single linear RF lesion (4-mm tip, 600 degrees C, 180 seconds) was created in each vena cava (from +/- 2 cm into the vein to the venoatrial junction) of 20 anesthetized minipigs (35 +/- 2 kg). Three groups were studied: acute (n = 4), killed 1 hour after RF; control (n = 8), sacrificed 83 +/- 1 days after RF; and pigs (n = 8) receiving hydrocortisone (400 mg i.v. after RF) and prednisone (25 mg po for 30 days), killed 83 +/- 1 days post-BE Angiography was performed before, immediately after ablation, and at follow-up. Then, animals were sacrificed for histological analysis.Results: Mild (< 40 %) or moderate (41-70 %) acute luminal narrowing occurred in 19/20 (95 %) inferior veins and in 13/20 (65%) superior veins. Severe (> 70%) stenosis and occlusions were not noted. At follow-up, in both chronic groups, mean vessel diameters returned to baseline and progression of luminal narrowing did not occur in any vein. of note, superior and inferior vena cava angiographic diameter for control and treated pigs did not differ. the same was observed for the cross-sectional luminal area. Acute lesions displayed transmural coagulative necrosis whereas chronic lesions revealed marked fibrosis. Histological findings were similar in controls and treated pigs.Conclusion: in this model, mild and moderate stenosis, occurring immediately after ablation, seems to resolve over time. Corticosteroids do not affect the long-term outcome of such RF lesions in the caval veins.
Palavra-chave arrhythmias
radiofrequency ablation
caval vein
stenosis
steroids
Idioma Inglês
Data de publicação 2008-08-01
Publicado em Pace-pacing and Clinical Electrophysiology. Oxford: Blackwell Publishing, v. 31, n. 8, p. 1010-1019, 2008.
ISSN 0147-8389 (Sherpa/Romeo, fator de impacto)
Publicador Blackwell Publishing
Extensão 1010-1019
Fonte http://dx.doi.org/10.1111/j.1540-8159.2008.01128.x
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000258397500011
Endereço permanente http://repositorio.unifesp.br/handle/11600/30838

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