Low-level laser therapy in the prevention and treatment of chemotherapy-induced oral mucositis in young patients

Low-level laser therapy in the prevention and treatment of chemotherapy-induced oral mucositis in young patients

Autor Fracher Abramoff, Meire Maman Google Scholar
Fontana Lopes, Nilza Nelly Autor UNIFESP Google Scholar
Lopes, Luciana Almeida Google Scholar
Dib, Luciano Lauria Google Scholar
Guilherme, Arnaldo Google Scholar
Caran, Eliana Monteiro Autor UNIFESP Google Scholar
Barreto, Adriana Delboni Google Scholar
Martinho Lee, Maria Lucia Autor UNIFESP Google Scholar
Petrilli, Antonio Sergio Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
NUPEN
Resumo Objective: A pilot clinical study was conducted to evaluate the efficacy and feasibility of low-level laser therapy (LLLT) in the prevention and treatment of chemotherapy (CT)-induced oral mucositis (OM) in young patients.Background Data: Besides compromising the patient's nutrition and well-being, oral mucositis represents a portal of entry into the body for microorganisms present in the mouth, which may lead to sepsis if there is hematological involvement. Oncologic treatment tolerance decreases and systemic complications may arise that interfere with the success of cancer treatment. LLLT appears to be an interesting alternative to other approaches to treating OM, due to its trophic, anti-inflammatory, and analgesic properties.Materials and Methods: Patients undergoing chemotherapy (22 cycles) without mucositis were randomized into a group receiving prophylactic laser-irradiation (group 1), and a group receiving placebo light treatment (group 2). Patients who had already presented with mucositis were placed in a group receiving irradiation for therapeutic purposes (group 3, with 10 cycles of CT). Serum granulocyte levels were taken and compared to the progression of mucositis.Results: in group 1, most patients (73%) presented with mucositis of grade 0 (p = 0.03 when compared with the placebo group), and 18% presented with grade 1. in group 2, 27% had no OM and did not require therapy. in group 3, the patients had marked pain relief (as assessed by a visual analogue scale), and a decrease in the severity of OM, even when they had severe granulocytopenia.Conclusion: the ease of use of LLLT, high patient acceptance, and the positive results achieved, make this therapy feasible for the prevention and treatment of OM in young patients.
Idioma Inglês
Data de publicação 2008-08-01
Publicado em Photomedicine and Laser Surgery. New Rochelle: Mary Ann Liebert Inc, v. 26, n. 4, p. 393-400, 2008.
ISSN 1549-5418 (Sherpa/Romeo, fator de impacto)
Publicador Mary Ann Liebert Inc
Extensão 393-400
Fonte http://dx.doi.org/10.1089/pho.2007.2144
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000259126200018
Endereço permanente http://repositorio.unifesp.br/handle/11600/30833

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