The other side of the coin: Beneficiary effect of omega-3 fatty acids in sudden unexpected death in epilepsy

The other side of the coin: Beneficiary effect of omega-3 fatty acids in sudden unexpected death in epilepsy

Author Scorza, Fulvio A. Autor UNIFESP Google Scholar
Cysneiros, Roberta M. Google Scholar
Arida, Ricardo M. Autor UNIFESP Google Scholar
Terra-Bustamante, Vera C. Google Scholar
Albuquerque, Marly de Google Scholar
Cavalheiro, Esper A. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
NPT UMC
Univ Presbiteriana Mackenzie
Abstract The epilepsies are the most common serious neurological condition. People with epilepsy have a two- to threefold increased risk of dying prematurely than those without epilepsy, and the most common epilepsy-related category of death is sudden unexpected death in epilepsy (SUDEP). the exact pathophysiological causes of SUDEP remain unknown, but it is very probable that cardiac arrhythmia during and between seizures plays a potential role. Although the pharmacological treatments available for the epilepsies have expanded, antiepileptic drugs are still limited in clinical efficacy. in this regard, several factors such as genetic, environmental, and social can contribute to the inefficacy of therapeutic outcome in patients with epilepsy. Among these factors, nutritional aspects, that is, omega-3 fatty acid deficiency, have an interesting role in this scenario. Animal and clinical studies have demonstrated that omega-3 fatty acids may be useful in the prevention and treatment of epilepsy. Moreover, as omega-3 fatty acids per se have been shown to reduce cardiac arrhythmias and sudden cardiac deaths, it has been proposed that omega-3 fatty acid supplementation in patients with refractory seizures may reduce seizures and seizure-associated cardiac arrhythmias and, hence, SUDEP. Given their relative safety and general health benefits, our update article summarizes the knowledge of the role of dietary omega-3 fatty acids in epilepsy. (c) 2008 Elsevier Inc. All rights reserved.
Keywords epilepsy
omega-3 fatty acids
heart
sudden death
SUDEP
Language English
Date 2008-08-01
Published in Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 13, n. 2, p. 279-283, 2008.
ISSN 1525-5050 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 279-283
Origin http://dx.doi.org/10.1016/j.yebeh.2008.04.011
Access rights Closed access
Type Review
Web of Science ID WOS:000257503300002
URI http://repositorio.unifesp.br/handle/11600/30826

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