Sulfated glycosaminoglycans of periurethral tissue in pre- and postmenopausal women

Sulfated glycosaminoglycans of periurethral tissue in pre- and postmenopausal women

Autor Feldner, Paulo Cezar Autor UNIFESP Google Scholar
Ferreira Sartori, Marair Gracio Autor UNIFESP Google Scholar
Nader, Helena B. Autor UNIFESP Google Scholar
Dietrich, Carl P. Autor UNIFESP Google Scholar
Lima, Geraldo Rodrigues de Autor UNIFESP Google Scholar
Baracat, Edmund Chada Autor UNIFESP Google Scholar
Batista Castello Girao, Manoel Joao Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Objective: the objective was to determine the sulfated glycosaminoglycans (GAGs) of the extracellular matrix (ECM) in pre- and postmenopausal women.Study design: Periurethral tissue was obtained from 44 consecutive women who underwent surgery for urinary incontinence, for pelvic organ prolapse, or for other gynecologic benign conditions. Biopsy specimens were assessed by biochemical methods to characterize and quantify,sulfated GAG. Measurements were made of total GAG, chondroitin sulfate, dermatan sulfate and of heparan sulfate. Data were compared using the t-test.Results: Patients were divided into two groups (pre- and postmenopausal groups) and dermatan sulfate was the most predominant glycosaminoglycan. Postmenopausal women had significantly less total sulfated glycosaminoglycans (p < 0.01), dermatan sulfate (p < 0.01) and chondroitin sulfate (p < 0.05) than premenopausal women. We did not observe any differences in heparan sulfate.Conclusions: Postmenopausal women showed quantitative differences in the biochemical characteristics of the ECM in periurethral tissue by analysis of sulfated GAG. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
Palavra-chave extracellular matrix
glycosaminoglycans
postmenopause
Idioma Inglês
Data de publicação 2008-08-01
Publicado em European Journal of Obstetrics & Gynecology and Reproductive Biology. Amsterdam: Elsevier B.V., v. 139, n. 2, p. 252-255, 2008.
ISSN 0301-2115 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 252-255
Fonte http://dx.doi.org/10.1016/j.ejogrb.2008.01.018
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000259059400023
Endereço permanente http://repositorio.unifesp.br/handle/11600/30822

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