Interleukin-6 and procalcitonin in children with sepsis and septic shock

Interleukin-6 and procalcitonin in children with sepsis and septic shock

Autor Fioretto, Jose R. Google Scholar
Martin, Joelma G. Google Scholar
Kurokawa, Cilmery S. Google Scholar
Carpi, Mario F. Google Scholar
Bonatto, Rossano C. Google Scholar
Ricchetti, Sandra M. Q. Google Scholar
Moraes, Marcos A. de Google Scholar
Padovani, Carlos R. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
São Paulo State Univ UNESP
Resumo Objectives. To examine the behavior of interleukin-6 (IL-6) and procalcitonin (PCT) and verify whether they can be used to differentiate children with septic conditions. Methods. Septic children aged between 28 days and 14 years, prospectively enrolled from 01/2004 to 12/2005, were divided into sepsis (SG; n = 47) and septic shock (SSG; n = 43) groups. IL-6 and PCT were measured at admission (TO) and 12 h later (T12h). PCT results were classed as: 0.5 ng/mL = sepsis unlikely; >= 0.5 to < 2 = sepsis possible; >= 2 to < 10 = systemic inflammation: >= 10 = septic shock. Results. Ninety children were included. At TO, there was a higher frequency of SSG with higher PCT compared with SG [SSG: 30 (69.7%) > SG: 14 (29.8%): p < 0.051. Similar results were observed at T12h. PRISM was significantly higher for SSG patients with higher PCT than SG patients. At TO, IL-6 levels were higher in SSG [SSG: 213.10 (10.85-396.70) > SG: 63.21 (0.86-409.82); p = 0.001], but not statistically different at T12h. IL-6 levels positively correlated with PRISM score in SSG patients at admission (p = 0.001; r = 0.86). Conclusion. PCT and IL-6 appear to be helpful in early assessment of pediatric sepsis, are of diagnostic value at admission, and are related to disease severity. (c) 2008 Elsevier B.V. All rights reserved.
Palavra-chave procalcitonin
interleukin-6
sepsis
septic shock
children
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Número do financiamento FAPESP: 04/03776-0
Data de publicação 2008-08-01
Publicado em Cytokine. London: Academic Press Ltd Elsevier B.V., v. 43, n. 2, p. 160-164, 2008.
ISSN 1043-4666 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 160-164
Fonte http://dx.doi.org/10.1016/j.cyto.2008.05.005
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000258893600010
Endereço permanente http://repositorio.unifesp.br/handle/11600/30821

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