Short-term administration of non-selective and selective cox-2 nsaids do not interfere with bone repair in rats

Short-term administration of non-selective and selective cox-2 nsaids do not interfere with bone repair in rats

Autor Matsumoto, Mariza Akemi Google Scholar
De Oliveira, Angelita Google Scholar
Ribeiro Junior, Paulo Domingos Google Scholar
Nary Filho, Hugo Google Scholar
Ribeiro, Daniel Araki Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Resumo Selective cyclooxygenase-2 non-steroidal anti-inflammatory drugs are known to inhibit bone repair, especially when long-term administration is required due to chronicle inflammatory diseases. in order to evaluate the action of this drug in bone repair during short-term administration, 48 rats underwent surgical bone defects in their tibias, being randomly distributed into three groups: (Group 1) negative control; (Group 2) animals treated with celecoxib, and (Group 3) animals treated with ketoprofen, both experimental groups at 1 mg/kg dose, beginning 1 h before the surgical procedure and after every 12 h for the following 3 days, or until the day of sacrifice. the animals were killed after 48 h, 7, 14, and 21 days. the tibias were removed for morphological, morphometric, and immunohistochemistry analysis for COX-2. No statistical significant differences were observed in the quality of bone repair and quantity of formed bone among the groups. COX-2 immunoreactivity of the celecoxib treated specimens was more intense in the first analyzed period, and no longer observed in the periods of 14 and 21 days. Such results suggest that the administration of the analyzed drugs in short periods does not interfere with the process of bone repair in the tibia of rats.
Palavra-chave COX-2
immunohistochemistry
rats
anti-inflammatory drugs
bone repair
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Número do financiamento FAPESP: 04/09748-9
Data de publicação 2008-08-01
Publicado em Journal of Molecular Histology. Dordrecht: Springer, v. 39, n. 4, p. 381-387, 2008.
ISSN 1567-2379 (Sherpa/Romeo, fator de impacto)
Publicador Springer
Extensão 381-387
Fonte http://dx.doi.org/10.1007/s10735-008-9176-z
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000258539400004
Endereço permanente http://repositorio.unifesp.br/handle/11600/30816

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