Effect of continuous positive airway pressure therapy on hypothalamic-pituitary-adrenal axis function and 24-h blood pressure profile in obese men with obstructive sleep apnea syndrome

Effect of continuous positive airway pressure therapy on hypothalamic-pituitary-adrenal axis function and 24-h blood pressure profile in obese men with obstructive sleep apnea syndrome

Autor Carneiro, Glaucia Autor UNIFESP Google Scholar
Togeiro, Sonia Maria Autor UNIFESP Google Scholar
Hayashi, Lilian F. Autor UNIFESP Google Scholar
Ribeiro-Filho, Fernando Flexa Autor UNIFESP Google Scholar
Ribeiro, Artur Beltrame Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Zanella, Maria Teresa Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Hosp Rim & Hipertensao
Resumo Obstructive sleep apnea syndrome (OSAS) increases the risk of cardiovascular events. Sympathetic nervous system and hypothalamic-pituitary-adrenal (HPA) axis activation may be the mechanism of this relationship. the aim of this study was to evaluate HPA axis and ambulatory blood pressure monitoring in obese men with and without OSAS and to determine whether nasal continuous positive airway pressure therapy (nCPAP) influenced responses. Twenty-four-hour ambulatory blood pressure monitoring and overnight cortisol suppression test with 0.25 mg of dexamethasone were performed in 16 obese men with OSAS and 13 obese men controls. Nine men with severe apnea were reevaluated 3 mo after nCPAP therapy. Body mass index and blood pressure of OSAS patients and obese controls were similar. in OSAS patients, the percentage of fall in systolic blood pressure at night (P = 0.027) and salivary cortisol suppression postdexamethasone (P = 0.038) were lower, whereas heart rate (P = 0.022) was higher compared with obese controls. After nCPAP therapy, patients showed a reduction in heart rate (P = 0.036) and a greater cortisol suppression after dexamethasone (P = 0.001). No difference in arterial blood pressure (P = 0.183) was observed after 3 mo of nCPAP therapy. Improvement in cortisol suppression was positively correlated with an improvement in apnea-hypopnea index during nCPAP therapy (r = 0.799, P = 0.010). in conclusion, men with OSAS present increased postdexamethasone cortisol levels and heart rate, which were recovered by nCPAP.
Palavra-chave sleep disorders
low-dose dexamethasone test
ambulatory blood pressure monitoring
Idioma Inglês
Data de publicação 2008-08-01
Publicado em American Journal of Physiology-endocrinology and Metabolism. Bethesda: Amer Physiological Soc, v. 295, n. 2, p. E380-E384, 2008.
ISSN 0193-1849 (Sherpa/Romeo, fator de impacto)
Publicador Amer Physiological Soc
Extensão E380-E384
Fonte http://dx.doi.org/10.1152/ajpendo.00780.2007
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000258133200019
Endereço permanente http://repositorio.unifesp.br/handle/11600/30811

Exibir registro completo




Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta