Low urinary 6-sulphatoxymelatonin concentrations in acute migraine

Low urinary 6-sulphatoxymelatonin concentrations in acute migraine

Autor Masruha, Marcelo Rodrigues Autor UNIFESP Google Scholar
Vieira, Domingos Sávio de Souza Autor UNIFESP Google Scholar
Minett, Thaís Soares Cianciarullo Autor UNIFESP Google Scholar
Cipolla-Neto, Jose Google Scholar
Zukerman, Eliova Autor UNIFESP Google Scholar
Vilanova, Luiz Celso Pereira Autor UNIFESP Google Scholar
Peres, Mario Fernando Prieto Autor UNIFESP Google Scholar
Instituição Hosp Israelita Albert Einstein
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Resumo Substantial evidence points to melatonin as playing a role in the regulation of circadian rhythms, sleep, and headache disorders. the objective of the study was to assess 6-sulphatoxymelatonin (aMT6s) levels in a large consecutive series of patients with migraine, comparing with controls. A total of 220 subjects were evaluated-146 had migraine and 74 were control subjects. Urinary samples were collected into the same plastic container since 8:00 p.m. to 8:00 a.m. of the next day (12-h period) and aMT6s was measured with quantitative ELISA technique. Among patients with migraine, 53% presented pain on the day of the urine samples collection. Their urinary aMT6s concentration was significantly lower than in the urine of patients without pain [14.0 +/- 7.3 vs. 49.4 +/- 19.0; t(143) = -15.1; 95% CI = -40.0 to -30.8; P<0.001]. There was no significant difference in the aMT6s concentration of patients with migraine without pain on the day of their urine samples collection and controls [49.4 +/- 19.0 vs. 42.5 +/- 27.9; t(140) = 1.7; 95% CI = -1.2 to 14.8; P = 0.094]. To our knowledge, this is the first study to demonstrate reduction in melatonin levels during attacks in episodic and chronic migraine.
Palavra-chave Circadian rhythm
Pathophysiology
Melatonin
Migraine
Headache
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Data de publicação 2008-08-01
Publicado em Journal of Headache and Pain. New York: Springer, v. 9, n. 4, p. 221-224, 2008.
ISSN 1129-2369 (Sherpa/Romeo, fator de impacto)
Publicador Springer
Extensão 221-224
Fonte http://dx.doi.org/10.1007/s10194-008-0047-5
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000260155700005
Endereço permanente http://repositorio.unifesp.br/handle/11600/30807

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