The frequency of CD127(low) expressing CD4(+)CD25(high) T regulatory cells is inversely correlated with human T lymphotrophic virus type-1 (HTLV-1) proviral load in HTLV-1-infection and HTLV-1-associated myelopathy/tropical spastic paraparesis

The frequency of CD127(low) expressing CD4(+)CD25(high) T regulatory cells is inversely correlated with human T lymphotrophic virus type-1 (HTLV-1) proviral load in HTLV-1-infection and HTLV-1-associated myelopathy/tropical spastic paraparesis

Autor Michaelsson, Jakob Google Scholar
Barbosa, Hugo Marcelo Ribeiro Autor UNIFESP Google Scholar
Jordan, Kimberley A. Google Scholar
Chapman, Joan M. Google Scholar
Brunialti, Milena Karina Coló Autor UNIFESP Google Scholar
Kleine Neto, Walter Google Scholar
Nukui, Youko Google Scholar
Sabino, Ester C. Google Scholar
Chieia, Marco Antonio Autor UNIFESP Google Scholar
Oliveira, Acary Souza Bulle Autor UNIFESP Google Scholar
Nixon, Douglas F. Google Scholar
Kallas, Esper Georges Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Univ Calif San Francisco
São Paulo Blood Bank
Universidade de São Paulo (USP)
Karolinska Inst
Resumo Background: CD4(+)CD25(high) regulatory T (T(Reg)) cells modulate antigen-specific T cell responses, and can suppress anti-viral immunity. in HTLV-1 infection, a selective decrease in the function of T(Reg) cell mediated HTLV-1-tax inhibition of FOXP3 expression has been described. the purpose of this study was to assess the frequency and phenotype of T(Reg) cells in HTLV-1 asymptomatic carriers and in HTLV-1-associated neurological disease (HAM/TSP) patients, and to correlate with measures of T cell activation.Results: We were able to confirm that HTLV-1 drives activation, spontaneous IFN gamma production, and proliferation of CD4+ T cells. We also observed a significantly lower proportion of CTLA-4(+) T(Reg) cells (CD4(+)CD25(high) T cells) in subjects with HAM/TSP patients compared to healthy controls. Ki-67 expression was negatively correlated to the frequency of CTLA-4(+) T(Reg) cells in HAM/TSP only, although Ki-67 expression was inversely correlated with the percentage of CD127(low) T(Reg) cells in healthy control subjects. Finally, the proportion of CD127(low) T(Reg) cells correlated inversely with HTLV-1 proviral load.Conclusion: Taken together, the results suggest that T(Reg) cells may be subverted in HAM/TSP patients, which could explain the marked cellular activation, spontaneous cytokine production, and proliferation of CD4(+) T cells, in particular those expressing the CD25(high)CD127(low) phenotype. T(Reg) cells represent a potential target for therapeutic intervention for patients with HTLV-1-related neurological diseases.
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
NIH
The Fogarty International Center
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Brazilian Ministry of Education
Número do financiamento FAPESP: 04/10918-6
NIH: A141531
NIH: A152731
NIH: A1060379
NIH: A1064520
The Fogarty International Center: D43 TW00003
Data de publicação 2008-07-29
Publicado em Bmc Immunology. London: Biomed Central Ltd, v. 9, 12 p., 2008.
ISSN 1471-2172 (Sherpa/Romeo, fator de impacto)
Publicador Biomed Central Ltd
Extensão 12
Fonte http://dx.doi.org/10.1186/1471-2172-9-41
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000258629800002
Endereço permanente http://repositorio.unifesp.br/handle/11600/30805

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