Targeting cancer stem cells with monoclonal antibodies: a new perspective in cancer therapy and diagnosis

Targeting cancer stem cells with monoclonal antibodies: a new perspective in cancer therapy and diagnosis

Autor Okamoto, Oswaldo Keith Autor UNIFESP Google Scholar
Perez, Jose Fernando Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo This review discusses some of the impacts that biotechnology, genomics and nanotechnology convergence should have on future cancer management, in particular, the development of innovative diagnostic and therapeutic approaches based on monoclonal antibodies (mAbs) and cancer stem cells. Emergent therapeutic strategies in cancer have been focusing on the use of mAbs to stimulate an immune response against tumors, to block signaling pathways, or to refine delivery of cytotoxic agents. Now that cancer stem cells are being identified and characterized in different tumor types, their relevance to cancer physiopathology is becoming evident, making them natural targets for mAb development. Cancer stem cells are postulated to be responsible for tumor development, metastasis and relapse after conventional therapies. Therefore, mAbs targeting specific antigens and related pathways altered in cancer stem cells should facilitate earlier diagnosis through molecular imaging techniques and more efficient destruction of tumor initiating cells, thus improving clinical outcome.
Palavra-chave biotechnology
cancer stem cell
molecular imaging
monoclonal antibody
target therapy
Idioma Inglês
Data de publicação 2008-07-01
Publicado em Expert Review of Molecular Diagnostics. London: Expert Reviews, v. 8, n. 4, p. 387-393, 2008.
ISSN 1473-7159 (Sherpa/Romeo, fator de impacto)
Publicador Expert Reviews
Extensão 387-393
Direito de acesso Acesso restrito
Tipo Resenha
Web of Science WOS:000257765700005
Endereço permanente

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