Performance of 3 methods for quality control for gynecologic cytology diagnoses

Performance of 3 methods for quality control for gynecologic cytology diagnoses

Autor Utagawa, Maria Lucia Google Scholar
Shirata, Neuza Kasumi Google Scholar
Mattosinho de Castro Ferraz, Maria da Gloria Google Scholar
di Loreto, Celso Google Scholar
Agnol, Miria Dall' Google Scholar
Longatto-Filho, Adhemar Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Univ Minho
Resumo ObjectiveTo evaluate performance and viability of internal quality control QC) strategies in a public health laboratory of the state of São Paulo.Study DesignA retrospective study was per formed with 3 QC strategies to improve internal cytologic diagnoses: morphologic guided-list criteria (MGLC), 100% rapid-rescreening (100% RR) of negative slides (turret method) and 10% rescreening (10% R) of negative slides. Cases were examined at Adolfo Lutz Institute, São Paulo, Brazil, from 2002 to 2004. Histopathologic results, when available, were considered gold standard; cytologic consensus diagnosis was by 2 pathologists when histologic results were unavailable.ResultsMGLC selected 20.7% samples with cytologic atypias, 10% R selected 0.6% and RR selected 2.5%. Cytologic/histologic initial concordance was 57.4%, low-grade squamous intraepithelial lesion false negative rate was 34.9% and high-grade squamous intraepithelial lesion false negative rate was 12.2%. After diagnosis, consensus concordance was 97.2%.ConclusionThe 100% RR and 10% R QC strategies detected more false negative cases in liquid-based cytology than in conventional Pap smears. the 100% RR strategy reduced the false negative results and allowed evaluation of individual staff performance. the 10% R strategy did not offer significant results. We concluded that association of MGLC and 100% RR strategies might improve cytologic diagnostic quality.
Palavra-chave cytologic technique
papanicolaou smear
quality control
Idioma Inglês
Data de publicação 2008-07-01
Publicado em Acta Cytologica. St Louis: Sci Printers & Publ Inc, v. 52, n. 4, p. 439-444, 2008.
ISSN 0001-5547 (Sherpa/Romeo, fator de impacto)
Publicador Sci Printers & Publ Inc
Extensão 439-444
Fonte http://dx.doi.org/10.1159/000325549
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000257964300008
Endereço permanente http://repositorio.unifesp.br/handle/11600/30795

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