Waist circumference and visceral fat in CKD: A cross-sectional study

Waist circumference and visceral fat in CKD: A cross-sectional study

Autor Sanches, Fabiana M. R. Autor UNIFESP Google Scholar
Avesani, Carla M. Autor UNIFESP Google Scholar
Kamimura, Maria Ayako Autor UNIFESP Google Scholar
Lemos, Marcelo M. Autor UNIFESP Google Scholar
Axelsson, Jonas Google Scholar
Vasselai, Priscila Autor UNIFESP Google Scholar
Draibe, Sergio A. Autor UNIFESP Google Scholar
Cuppari, Lilian Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Karolinska Inst
Resumo Background: in the general population, waist circumference was noted to be a reliable predictor of visceral fat. in addition, increased waist circumference was strongly associated with risk factors for cardiovascular disease. in patients with chronic kidney disease (CKD), the association of waist circumference with visceral fat was never tested.Study Design: Cross-sectional study.Setting & Participants: 122 patients with CKD not yet on dialysis therapy (75 men; diabetes mellitus, 30%; age, 55.3 +/- 11.3 years; body mass index, 27.1 +/- 5.2 kg/m(2); estimated glomerular filtration rate, 35.4 +/- 15.2 mL/min/1.73 m(2)) were studied.Predictor: Waist circumference.Outcomes & Measurements: Anthropometry, abdominal visceral fat measured by means of computed tomography, and cardiovascular disease risk factors.Results: Waist circumference strongly correlated with visceral fat (r = 0.75 for men, r = 0.81 for women; P < 0.01). K Statistic was 0.56, indicating relatively good agreement between methods. Body mass index showed a lower correlation coefficient (r = 0.68 for men, r = 0.76 for women; P < 0.01) and poor agreement (0.36) with visceral fat in comparison to waist circumference. in men, waist circumference and visceral fat similarly correlated with high-density lipoprotein cholesterol level, triacylglycerol level, and Homeostasis Model Assessment Index (P < 0.05). in women, waist circumference correlated with age, C-reactive protein level, and Homeostasis Model Assessment Index, whereas visceral fat also correlated with low-density lipoprotein cholesterol and triacylglycerol levels (P < 0.05).Limitations: Findings are restricted to patients with CKD not yet on dialysis therapy from a single center.Conclusions: Waist circumference was strongly associated with visceral fat in patients with CKD. Associations between waist circumference and cardiovascular disease risk factors were similar to those observed for visceral fat, particularly in men. These findings suggest that waist circumference may be a simple and inexpensive too] to be used in epidemiological studies.
Palavra-chave abdominal obesity
insulin resistance
metabolic syndrome
cardiovascular disease
end-stage renal disease
Idioma Inglês
Data de publicação 2008-07-01
Publicado em American Journal of Kidney Diseases. Philadelphia: W B Saunders Co-Elsevier Inc, v. 52, n. 1, p. 66-73, 2008.
ISSN 0272-6386 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 66-73
Fonte http://dx.doi.org/10.1053/j.ajkd.2008.02.004
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000257886600010
Endereço permanente http://repositorio.unifesp.br/handle/11600/30784

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