Temporal lobe epilepsy and social behavior: An animal model

Temporal lobe epilepsy and social behavior: An animal model

Autor Marin, Joao Carlos M. Autor UNIFESP Google Scholar
Moura, Paula J. Google Scholar
Cysneiros, Roberta M. Google Scholar
Colugnati, Diego Basile Autor UNIFESP Google Scholar
Cavalheiro, Esper A. Google Scholar
Scorza, Fulvio A. Google Scholar
Xavier, Gilberto F. Google Scholar
Zilbovicius, Monica Google Scholar
Mercadante, Marcos T. Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
CEA
Resumo Social behavior depends on the integrity of social brain circuitry. the temporal lobe is an important part of the social brain, and manifests morphological and functional alterations in autism spectrum disorders (ASD). Rats with temporal lobe epilepsy (TLE), induced with pilocarpine, were subjected to a social discrimination test that has been used to investigate potential animal models of ASD, and the results were compared with those for the control group. Rats with TLE exhibited fewer social behaviors than controls. No differences were observed in nonsocial behavior between groups. the results suggest an important role for the temporal lobe in regulating social behaviors. This animal model might be used to explore some questions about ASD pathophysiology. (c) 2008 Elsevier Inc. All rights reserved.
Palavra-chave temporal lobe epilepsy
social behavior
social inemory
social discrimination paradigm
autism animal model
pilocarpine
Idioma Inglês
Data de publicação 2008-07-01
Publicado em Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 13, n. 1, p. 43-46, 2008.
ISSN 1525-5050 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 43-46
Fonte http://dx.doi.org/10.1016/j.yebeh.2008.03.004
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000257009400009
Endereço permanente http://repositorio.unifesp.br/handle/11600/30781

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