Behavioral characterization of pentylenetetrazol-induced seizures in the marmoset

Behavioral characterization of pentylenetetrazol-induced seizures in the marmoset

Autor Bachiega, Joao C. Autor UNIFESP Google Scholar
Blanco, Miriam M. Autor UNIFESP Google Scholar
Perez-Mendes, Patricia Autor UNIFESP Google Scholar
Cinini, Simone Maria Autor UNIFESP Google Scholar
Covolan, Luciene Autor UNIFESP Google Scholar
Mello, Luiz E. Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo This study was designed to characterize seizures induced with pentylenetetrazol (PTZ) in marmosets. Thirteen adult marmosets (Callithrix sp.) received 20, 30, or 40 mg/kg of PTZ intraperitoneally. PTZ caused all animals to switch their natural behavioral repertoire to early convulsive behavior. Seizure scores were low at lower PTZ doses, whereas the highest dose of PTZ led to seizure scores IV and V (according to Racine's scale) in 69% of animals. To further characterize the model we performed a preliminary evaluation of the efficacy of three antiepileptic drugs: phenobarbital, phenytoin, and carbamazepine. Phenobarbital prevented PTZ-induced seizures in 100% of trials. As expected, phenytoin and carbamazepine were not effective against PTZ-induced seizures. the present study describes the PTZ model of seizures in marmosets with a drug-response profile similar to that of the rodent model, thus bringing to a well-known model (PTZ in rodents) the complexity of a nonhuman primate brain. (c) 2008 Elsevier Inc. All rights reserved.
Assunto marmoset
antiepileptic drugs
epilepsy model
Idioma Inglês
Data 2008-07-01
Publicado em Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 13, n. 1, p. 70-76, 2008.
ISSN 1525-5050 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 70-76
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000257009400013

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