Neuroprotective activity of omega-3 fatty acids against epilepsy-induced hippocampal damage: Quantification with immunohistochemical for calcium-binding proteins

Neuroprotective activity of omega-3 fatty acids against epilepsy-induced hippocampal damage: Quantification with immunohistochemical for calcium-binding proteins

Autor Ferrari, Danuza Autor UNIFESP Google Scholar
Cysneiros, Roberta Monterazzo Autor UNIFESP Google Scholar
Scorza, Carla A. Autor UNIFESP Google Scholar
Arida, Ricardo M. Autor UNIFESP Google Scholar
Cavalheiro, Esper A. Autor UNIFESP Google Scholar
Almeida, Antonio-Carlos G. de Google Scholar
Scorza, Fulvio A. Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo To investigate whether n-3 polyunsaturated fatty acids (n-3 PUFAs) would promote different morphological changes in the hippocampal formation of rats with epilepsy, we performed an immunocytochemical study using parvalbumin (PV) and calretinin (CR) distribution as a marker. Animals subjected to the experimental model of epilepsy with a single dose of pilocarpine were randomly divided into the following groups: animals with epilepsy treated daily with vehicle (EV) and animals with epilepsy treated daily with 85 mg/kg n-3 PUFAs (EW). Control animals administered saline were also randomly divided into two other groups: animals treated daily with vehicle (CV) and animals treated daily with 85 mg/kg n-3 PUFAs (CW). A larger number of PV-positive neurons were observed in EW when compared with EV, CV, and CW. Similarly, there were significantly more CR-positive neurons in EW than in EV. These findings demonstrate that omega-3 fatty acids prevent status epilepticus-associated neuropathological changes in the hippocampal formation of rats with epilepsy. (c) 2008 Elsevier Inc. All rights reserved.
Assunto n-3 polyunsaturated fatty acids
pilocarpine
epilepsy
neuroprotection
calcium-binding proteins
Idioma Inglês
Data 2008-07-01
Publicado em Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 13, n. 1, p. 36-42, 2008.
ISSN 1525-5050 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 36-42
Fonte http://dx.doi.org/10.1016/j.yebeh.2008.01.001
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000257009400008
URI http://repositorio.unifesp.br/handle/11600/30778

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