Endometrial leukemia inhibitory factor as a predictor of pregnancy after in vitro fertilization

Endometrial leukemia inhibitory factor as a predictor of pregnancy after in vitro fertilization

Autor Serafini, Paulo Google Scholar
Rocha, Andre M. Google Scholar
Osorio, Cyntia T. Google Scholar
Silva, Ismael da Autor UNIFESP Google Scholar
Motta, Eduardo L. Autor UNIFESP Google Scholar
Baracat, Edmund C. Google Scholar
Instituição Huntington Reproduct Ctr
Universidade de São Paulo (USP)
Hosp Canc AC Camargo
Universidade Federal de São Paulo (UNIFESP)
Resumo Objective: To determine whether there is an association between endometrial expression of leukemia inhibitory factor (LIF) in the luteal phase of the menstrual cycle preceding in vitro fertilization (IVF) and treatment outcome. Methods: Biopsy specimens from the endometria of 52 women in the luteal. phase were immunostained against LIF Embryo culture and transfer were done according to standard procedures. Results: Clinical pregnancy occurred in 39% of the women following IVF, and strong endometrial immunohistochemical staining for LIF was associated with pregnancy (P=0.01). the women with a strong LIF expression had a 6.4-fold higher chance of becoming pregnant than those with weaker intensities (P=0.005). Conclusion: Endometrial expression of LIF during the luteal phase can be used as a predictor of IVF success. (C) 2008 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
Palavra-chave endometrial biopsy
endometrial receptivity
in vitro fertilization
leukemia inhibitory factor
luteal phase
tissue microarray
Idioma Inglês
Data de publicação 2008-07-01
Publicado em International Journal of Gynecology & Obstetrics. Clare: Elsevier B.V., v. 102, n. 1, p. 23-27, 2008.
ISSN 0020-7292 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 23-27
Fonte http://dx.doi.org/10.1016/j.ijgo.2007.12.005
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000257613500006
Endereço permanente http://repositorio.unifesp.br/handle/11600/30760

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