Endometrial leukemia inhibitory factor as a predictor of pregnancy after in vitro fertilization

Endometrial leukemia inhibitory factor as a predictor of pregnancy after in vitro fertilization

Author Serafini, Paulo Google Scholar
Rocha, Andre M. Google Scholar
Osorio, Cyntia T. Google Scholar
Silva, Ismael da Autor UNIFESP Google Scholar
Motta, Eduardo L. Autor UNIFESP Google Scholar
Baracat, Edmund C. Google Scholar
Institution Huntington Reproduct Ctr
Universidade de São Paulo (USP)
Hosp Canc AC Camargo
Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: To determine whether there is an association between endometrial expression of leukemia inhibitory factor (LIF) in the luteal phase of the menstrual cycle preceding in vitro fertilization (IVF) and treatment outcome. Methods: Biopsy specimens from the endometria of 52 women in the luteal. phase were immunostained against LIF Embryo culture and transfer were done according to standard procedures. Results: Clinical pregnancy occurred in 39% of the women following IVF, and strong endometrial immunohistochemical staining for LIF was associated with pregnancy (P=0.01). the women with a strong LIF expression had a 6.4-fold higher chance of becoming pregnant than those with weaker intensities (P=0.005). Conclusion: Endometrial expression of LIF during the luteal phase can be used as a predictor of IVF success. (C) 2008 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
Keywords endometrial biopsy
endometrial receptivity
in vitro fertilization
leukemia inhibitory factor
luteal phase
tissue microarray
Language English
Date 2008-07-01
Published in International Journal of Gynecology & Obstetrics. Clare: Elsevier B.V., v. 102, n. 1, p. 23-27, 2008.
ISSN 0020-7292 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 23-27
Origin http://dx.doi.org/10.1016/j.ijgo.2007.12.005
Access rights Closed access
Type Article
Web of Science ID WOS:000257613500006
URI http://repositorio.unifesp.br/handle/11600/30760

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