Effects of hexestrol on mouse ovarian morphology and ovulation

Effects of hexestrol on mouse ovarian morphology and ovulation

Autor Oliveira, Joaquim Moraes de Autor UNIFESP Google Scholar
Simoes, Manuel J. Autor UNIFESP Google Scholar
Mora, Oswaldo Alves Autor UNIFESP Google Scholar
Simoes, Ricardo Santos Autor UNIFESP Google Scholar
Oliveira-Filho, Ricardo M. Autor UNIFESP Google Scholar
Oliveira, Patricia B. Autor UNIFESP Google Scholar
Baracat, Edmund C. Autor UNIFESP Google Scholar
Soares, Jose Maria Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Objective: To analyze histological aspects of ovaries as well as the ovulation of adult mice treated with the anabolic agent hexestrol.Methods: Thirty adult mice were divided into three groups of 10 animals each: (GI) the animals received a dose of 3 mg/kg of hexestrol; (GII) the animals were given a dose of 6 mg/kg of hexestrol; (GIII) the animals were injected with distilled water (vehicle). Another 10-animal group (GIV) was included, and these mice were injected with propionate testosterone (1.25 mg) after 5 days from the day of birth. Hexestrol was administered intraperitoneally once a day and the treatment lasted 30 days. the mice were then sacrificed; their ovaries and oviducts were removed, submitted to histological routine and analyzed under light microscopy.Results: in mice treated with hexestrol (6 mg/kg) (Group II), ovaries were smaller than those from the controls but highly vascularized; similar results were obtained in GIV. A great number of follicles in several stages of development were found however, with no corpora lutea - in six animals in GII No corpora lutea were found in GIV. the number of luteal bodies and oocytes in GII was lower than that in GI or GIII. No oocytes were detected in GIV. Finally, the nuclear volume of interstitial cells in GII and GIV was the largest.Conclusion: Our data suggest that the anabolic agent hexestrol in a high dose may decrease ovulation in mice. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
Assunto hexestrol
Idioma Inglês
Data 2008-06-20
Publicado em Maturitas. Clare: Elsevier B.V., v. 60, n. 2, p. 153-157, 2008.
ISSN 0378-5122 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 153-157
Fonte http://dx.doi.org/10.1016/j.maturitas.2008.05.002
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000258048700009
URI http://repositorio.unifesp.br/handle/11600/30735

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