Increase in bax expression and apoptosis are associated in Huntington's disease progression

Increase in bax expression and apoptosis are associated in Huntington's disease progression

Autor Teles, A. V. F. F. Autor UNIFESP Google Scholar
Rosenstock, T. R. Autor UNIFESP Google Scholar
Okuno, C. S. Autor UNIFESP Google Scholar
Lopes, G. S. Autor UNIFESP Google Scholar
Bertoncini, C. R. A. Autor UNIFESP Google Scholar
Smaili, S. S. Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Huntington's disease (HD) is a hereditary dominant neurodegenerative disorder and the progression of the disease may be associated with apoptosis and altered expression of apoptotic proteins. the aim of this study was to investigate gene expression of bax and bcl-2 in tissues from R6/1 transgenic (TGN) mice of different ages (3, 6 and 9 months). the mRNA expression was investigated and related to apoptotic cells measured by TUNEL Results showed a significant and progressive increase in box levels in the cortex of TGN (from 10 to 33%) when compared to control (CT) (8 to 20%) mice with 3, 6 and 9-month-old. the increase in box was correlated with the elevation in the number of apoptotic nuclei, especially in the cortex of 6 (10%) and 9 (18%)-month-old mice. Increase in bax expression might be related to an apoptotic induction which contributes to the HD progression. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
Palavra-chave bcl-2
bax
mRNA
apoptosis
aging
Huntington's disease
neurodegeneration
cell death
Idioma Inglês
Data de publicação 2008-06-13
Publicado em Neuroscience Letters. Clare: Elsevier B.V., v. 438, n. 1, p. 59-63, 2008.
ISSN 0304-3940 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 59-63
Fonte http://dx.doi.org/10.1016/j.neulet.2008.03.062
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000257152000014
Endereço permanente http://repositorio.unifesp.br/handle/11600/30730

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