Intermittent hypoxia and sleep restriction: Motor, cognitive and neurochemical alterations in rats

Intermittent hypoxia and sleep restriction: Motor, cognitive and neurochemical alterations in rats

Autor Perry, Juliana C. Autor UNIFESP Google Scholar
D'Almeida, Vania Autor UNIFESP Google Scholar
Lima, Marcelo M. S. Autor UNIFESP Google Scholar
Godoi, Francisco R. L. Autor UNIFESP Google Scholar
Vital, Maria Aparecida B. F. Google Scholar
Oliveira, Maria Gabriela A. Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Univ Fed Parana
Resumo The present study evaluated the effects of intermittent hypoxia (IH) and sleep restriction (SR) upon motor and cognitive function in rats. Also evaluated were catecholamine concentrations and tyrosinehydroxylase (TH) protein expression in different regions of the forebrain. Wistar Hannover rats were submitted to IH for 4 days or 21 days (2 min room air to 2 min 10% 02 for 10:00-16:00 h), followed by SR for 18 h (16:00-10:00 h). Rats were randomly assigned into four experimental groups: (1) control (2) IH (3) SR and (4) IH-SR. in the inhibitory avoidance task, an additional group of rats was submitted to paradoxical sleep deprivation (PSD) for 96 consecutive hours. Results showed that SR induced an increase in motor activity without modifying catecholaminergic turnover in the frontal cortex and striatum. the increase in exploratory activity in SR rats could be the result of impaired habituation. Neither SR periods induced cognitive deficits in the inhibitory avoidance task after 5 or 21 days. However, 96 h of PSD impaired acquisition/retention in rats. Exposure to IH did not affect motor and cognitive function but IH was associated with SR in increased motor activity. After 21 days, IH and IH-SR reduced striatal norepinephrine concentration although neither SR nor IH affected TH protein expression. the results presented here suggest that hypoxia and sleep loss exert distinct deleterious effects upon the central nervous system. (C) 2008 Elsevier B.V. All rights reserved.
Assunto hypoxia
sleep deprivation
Idioma Inglês
Data 2008-06-03
Publicado em Behavioural Brain Research. Amsterdam: Elsevier B.V., v. 189, n. 2, p. 373-380, 2008.
ISSN 0166-4328 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 373-380
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000255604300017

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