High levels of Granzyme B expression in invasive cervical carcinoma correlates to poor response to treatment

Author	Guzman, Valeska B. Silva, Ismael Dale Cotrim Guerreiro da Brenna, Sylvia M. F. Carvalho, Carmen R. N. Ribalta, Julisa Chamorro Lascalas Gerbase-Lima, Maria
Institution	Universidade Federal de São Paulo (UNIFESP) Leonor Mendes Barros Hosp
Abstract	The present study assessed, in cervical carcinoma, expression levels of seven immune response genes and sought correlation to response to treatment. the expression levels of C,026, CTLA4, ICOS, ICOSL, CD80 and CD86 and granzyme B genes were assessed by real-time RTPCR in pre-treatment tumor fragments. During the six-month follow-up after treatment, 8 patients presented tumor and 10 survived free of tumor. the only gene whose expression levels, were higher in patients with poor outcome (p = 0.03) was granzyme B. Further evaluation, in adequately powered prospective studies is warranted to confirm the data and to translate this observation to the clinical setting.
Keywords	Granzyme B mRNA clinical outcome cervical cancer treatment
Language	English
Date	2008-06-01
Published in	Cancer Investigation. Philadelphia: Taylor & Francis Inc, v. 26, n. 5, p. 499-503, 2008.
ISSN	0735-7907 (Sherpa/Romeo, impact factor)
Publisher	Taylor & Francis Inc
Extent	499-503
Origin	http://dx.doi.org/10.1080/07357900701805678
Access rights	Closed access
Type	Article
Web of Science ID	WOS:000256917400009
URI	http://repositorio.unifesp.br/handle/11600/30714

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