High levels of Granzyme B expression in invasive cervical carcinoma correlates to poor response to treatment

High levels of Granzyme B expression in invasive cervical carcinoma correlates to poor response to treatment

Author Guzman, Valeska B. Autor UNIFESP Google Scholar
Silva, Ismael Dale Cotrim Guerreiro da Autor UNIFESP Google Scholar
Brenna, Sylvia M. F. Google Scholar
Carvalho, Carmen R. N. Autor UNIFESP Google Scholar
Ribalta, Julisa Chamorro Lascalas Autor UNIFESP Google Scholar
Gerbase-Lima, Maria Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Leonor Mendes Barros Hosp
Abstract The present study assessed, in cervical carcinoma, expression levels of seven immune response genes and sought correlation to response to treatment. the expression levels of C,026, CTLA4, ICOS, ICOSL, CD80 and CD86 and granzyme B genes were assessed by real-time RTPCR in pre-treatment tumor fragments. During the six-month follow-up after treatment, 8 patients presented tumor and 10 survived free of tumor. the only gene whose expression levels, were higher in patients with poor outcome (p = 0.03) was granzyme B. Further evaluation, in adequately powered prospective studies is warranted to confirm the data and to translate this observation to the clinical setting.
Keywords Granzyme B
mRNA
clinical outcome
cervical cancer
treatment
Language English
Date 2008-06-01
Published in Cancer Investigation. Philadelphia: Taylor & Francis Inc, v. 26, n. 5, p. 499-503, 2008.
ISSN 0735-7907 (Sherpa/Romeo, impact factor)
Publisher Taylor & Francis Inc
Extent 499-503
Origin http://dx.doi.org/10.1080/07357900701805678
Access rights Closed access
Type Article
Web of Science ID WOS:000256917400009
URI http://repositorio.unifesp.br/handle/11600/30714

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