A non-anticoagulant heterofucan has antithrombotic activity in vivo

A non-anticoagulant heterofucan has antithrombotic activity in vivo

Author Barroso, Edjane M. A. Google Scholar
Costa, Leandro S. Google Scholar
Medeiros, Valquiria P. Autor UNIFESP Google Scholar
Cordeiro, Sara L. Google Scholar
Costa, Mariana S. S. P. Google Scholar
Franco, Celia R. C. Google Scholar
Nader, Helena B. Autor UNIFESP Google Scholar
Leite, Edda L. Google Scholar
Rocha, Hugo A. O. Google Scholar
Institution Univ Fed Rio Grande do Norte
Universidade Federal de São Paulo (UNIFESP)
Univ Fed Parana
Abstract Fucan is a term used to denominate a family of sulfated L-fucose-rich polysaccharides. the brown alga Spatoglossum schroederi(Dictyotaceae) has three heterofucans namely fucan A, B and C. the 21 kDa fucan A is composed of a core of a beta (1-3) glucuronic acid-containing oligosaccharide of 4.5 kDa with branches at C4 of the fucose chains a (1-3) linked. the fucose is mostly substituted at C4 with a sulfate group and at C2 with chains of beta (1-4) xylose. This fucan has neither anticoagulant (from from 0.1 to 100 mu g) nor hemorrhagic activities (from 50 to 800 mu g/mL). the antithrombotic test in vivo showed that fucan A has no activity in any of the concentrations (from 0.2 to 20 mu g/g/day) tested 1 h after polysaccharide administration. However, when fucan A was injected endovenously 24 h before the ligature of the venae cavae, we observed a dose-dependent effect, reaching saturation at around 20 mu g/g of rat weight. in addition, this effect is also time-dependent, reaching saturation around 16 h after fucan administration. in addition, regardless of the administration route, fucan A displayed antithrombotic activity. the exception was the oral pathway. of particular importance was the finding that fucan A stimulates the synthesis of an antithrombotic heparan sulfate from endothelial cells like heparin. the hypothesis has been raised that the in vivo antithrombotic activity of fucan A is related to the increased production of this heparan. Taken together with the fact that the compound is practically devoid of anticoagulant and hemorrhagic activity, the data suggest that it may be an ideal antithrombotic agent in vivo.
Keywords brown algae
anticoagulant drugs
antithrombotic agents
Spatoglossum schroederi
Language English
Date 2008-06-01
Published in Planta Medica. Stuttgart: Georg Thieme Verlag Kg, v. 74, n. 7, p. 712-718, 2008.
ISSN 0032-0943 (Sherpa/Romeo, impact factor)
Publisher Georg Thieme Verlag Kg
Extent 712-718
Origin http://dx.doi.org/10.1055/s-2008-1074522
Access rights Closed access
Type Article
Web of Science ID WOS:000257284700002
URI http://repositorio.unifesp.br/handle/11600/30713

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