GFR estimated from cystatin C versus creatinine in children born small for gestational age

GFR estimated from cystatin C versus creatinine in children born small for gestational age

Autor Franco, Maria C. P. Autor UNIFESP Google Scholar
Nishida, Sonia K. Autor UNIFESP Google Scholar
Sesso, Ricardo Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Background: Low birth weight caused by intrauterine growth restriction may be a risk factor for renal impairment in the adult life.Study Design: A cross-sectional study.Setting & Participants: 71 children aged 8 to 13 years living in the community of São Paulo, Brazil, were included in the study. Gestational age was within the normal range.Predictors: Birth weight (range, 2,052 to 3,560 g) divided into quartiles: 2,500 g or less; 2,501 to 2,740 g; 2,741 to 3,000 g; and greater than 3,000 g. Birth weight ascertained by birth records in 43 and by recall in 28 participants.Outcomes & Measurements: Cystatin C, creatinine, and glomerular filtration rate (GFR) estimated by equations using cystatin C (eGFR(cys)) or creatinine (eGFR(cr)).Results: Overall, mean serum creatinine level was 0.8 +/- 0.01 (SE) mg/dL (range, 0.7 to 1.1 mg/dL); mean plasma cystatin C level was 0.9 +/- 0.02 mg/L (range, 0.5 to 1.6 mg/L), and eGFR(cr) and eGFR(cys) were 102.4 +/- 2.16 (range, 66 to 140) and 91.8 +/- 2.46 mL/min/1.73 m(2) (range, 49 to 139 mL/min/1.73 m(2)), respectively. No differences were found for serum creatinine or eGFR(cr) values among the birth-weight quartiles. There was a significant linear trend of increasing cystatin C levels (decreasing eGFR(cys) in the lower birth-weight quartile groups (P = 0.002 and P = 0.02, respectively). Systolic blood pressure correlated with plasma cystatin C level (r = 0.31; P = 0.008) and eGFR(cys) (r = -0.26; P = 0.028). Covariance analysis adjusting for age, sex, body mass index for age compared with standards of the National Center for Health Statistics and expressed as a z score, and systolic blood pressure showed that cystatin C values remained greater in the lowest than highest birth-weight quartile (1.01 +/- 0.05 versus 0.83 +/- 0.05 mg/L; P = 0.02).Limitations: Ascertainment of birth weight by recall in some participants. Lack of measurement of microalbuminuria, absence of direct GFR measurement, and small sample size.Conclusions: Lower birth weight is associated with higher levels of cystatin C but not creatinine in 8-13 yr. old children born full-term.
Palavra-chave intrauterine growth restriction
cystatin C
glomerular filtration rate
birth weight
Idioma Inglês
Data de publicação 2008-06-01
Publicado em American Journal of Kidney Diseases. Philadelphia: W B Saunders Co-Elsevier Inc, v. 51, n. 6, p. 925-932, 2008.
ISSN 0272-6386 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 925-932
Fonte http://dx.doi.org/10.1053/j.ajkd.2008.02.305
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000256551700010
Endereço permanente http://repositorio.unifesp.br/handle/11600/30712

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