Immune cellular parameters of leprosy and human immunodeficiency virus-1 co-infected subjects

Show simple item record Carvalho, Karina I. [UNIFESP] Maeda, Solange [UNIFESP] Marti, Luciana Yamashita, Jane [UNIFESP] Haslett, Patrick A. J. Kallas, Esper Georges [UNIFESP] 2016-01-24T13:51:24Z 2016-01-24T13:51:24Z 2008-06-01
dc.identifier.citation Immunology. Malden: Wiley-Blackwell, v. 124, n. 2, p. 206-214, 2008.
dc.identifier.issn 0019-2805
dc.description.abstract Leprosy and human immunodeficiency virus-1 (HIV-1) are examples of human infections where interactions between the pathogen and the host cellular immunity determine the clinical manifestations of disease. Hence, a significant immunopathological interaction between HIV-1 and leprosy might be expected. in the present study we explored several aspects of cellular immunity in patients co-infected with HIV-1 and Mycobacterium leprae. Twenty-eight individuals were studied, comprising four groups: healthy controls, HIV-1 and M. leprae co-infection, HIV-1 mono-infection, and M. leprae mono-infection. Subjects in the mono-infection and co-infection groups were matched as far as possible for bacillary load and HIV disease status, as appropriate. Peripheral blood mononuclear cells (PBMC) were analysed using six- and seven-colour flow cytometry to evaluate T-cell subpopulations and their activation status, dendritic cell (DC) distribution phenotypes and expression of IL-4 by T cells. the co-infected group exhibited lower CD4 : CD8 ratios, higher levels of CD8(+) T-cell activation, increased V delta 1 : V delta 2 T cell ratios and decreased percentages of plasmacytoid DC, compared with HIV-1 mono-infected subjects. Across infected groups, IL-4 production by CD4(+) T lymphocytes was positively correlated with the percentage of effector memory CD4(+) T cells, suggesting antigenically driven differentiation of this population of T cells in both HIV-1 and M. leprae infections. Co-infection with M. leprae may exacerbate the immunopathology of HIV-1 disease. A T helper 2 (Th2) bias in the CD4(+) T-cell response was evident in both HIV-1 infection and leprosy, but no additive effect was apparent in co-infected patients. en
dc.format.extent 206-214
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Immunology
dc.rights Acesso aberto
dc.subject HIV en
dc.subject leprosy en
dc.subject co-infection en
dc.subject lymphocytes en
dc.subject IL-4 en
dc.title Immune cellular parameters of leprosy and human immunodeficiency virus-1 co-infected subjects en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Univ Miami
dc.contributor.institution Albert Einstein Res Inst
dc.description.affiliation Universidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliation Univ Miami, Coral Gables, FL 33124 USA
dc.description.affiliation Albert Einstein Res Inst, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, São Paulo, Brazil
dc.identifier.doi 10.1111/j.1365-2567.2007.02756.x
dc.description.source Web of Science
dc.identifier.wos WOS:000255924900007


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