Exercise training prevents beta-adrenergic hyperactivity-induced myocardial hypertrophy and lesions

Exercise training prevents beta-adrenergic hyperactivity-induced myocardial hypertrophy and lesions

Author Serra, Andrey Jorge Autor UNIFESP Google Scholar
Higuchi, Maria L. Google Scholar
Ihara, Silvia Saiuli Miki Autor UNIFESP Google Scholar
Antonio, Ednei Luiz Autor UNIFESP Google Scholar
Santos, Marilia H. H. Google Scholar
Bombig, Maria Teresa Nogueira Autor UNIFESP Google Scholar
Tucci, Paulo José Ferreira Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Background: Sustained beta-adrenoreceptor activation promotes cardiac hypertrophy and cellular injury.Aims: To evaluate the cardioprotective effect of exercise on damage induced by beta-adrenergic hyperactivity.Methods: Male Wistar rats were randomised into four groups (n=8 per group): sedentary non-treated control (C), sedentary treated with isoproterenol 0.3 mg/kg/day administered subcutaneously for 8 days (1), exercised non-treated (E) and exercised plus isoproterenol administered during the last eight days of exercise (IE). Exercised animals ran on a treadmill for 1 h daily 6 times a week for 13 weeks.Results: Isoproterenol caused increases in left ventricle (LV) wet and dry weight/body weight ratio, LV water content and cardiomyocyte transverse diameter. Additionally, isoproterenol induced severe cellular lesions, necrosis, and apoptosis, increased collagen content and reduced capillary and fibre fractional areas. Notably, all of these abnormalities were completely prevented by exercise.Conclusion: Our data have demonstrated that complete cardioprotection is possible through exercise training; by preventing p-adrenergic hyperactivity-induced cardiac hypertrophy and structural injury. (c) 2008 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
Keywords myocardial hypertrophy
isoproterenol
exercise training
cardioprotection
Language English
Date 2008-06-01
Published in European Journal of Heart Failure. Amsterdam: Elsevier B.V., v. 10, n. 6, p. 534-539, 2008.
ISSN 1388-9842 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 534-539
Origin http://dx.doi.org/10.1016/j.ejheart.2008.03.016
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000257618500003
URI http://repositorio.unifesp.br/handle/11600/30670

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