Effects of sleep loss on sleep architecture in Wistar rats: Gender-specific rebound sleep

Effects of sleep loss on sleep architecture in Wistar rats: Gender-specific rebound sleep

Author Andersen, M. L. Autor UNIFESP Google Scholar
Antunes, I. B. Autor UNIFESP Google Scholar
Silva, A. Autor UNIFESP Google Scholar
Alvarenga, T. A. F. Autor UNIFESP Google Scholar
Baracat, E. C. Autor UNIFESP Google Scholar
Tufik, S. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract This study was designed to examine the influence of gender on sleep rebound architecture after a 4-day paradoxical sleep deprivation period. After a 5-day baseline sleep recording, both male and female rats in different phases of the estrus cycle were submitted to paradoxical sleep deprivation for 96 h. After this period, the sleep rebound recording was evaluated for 5 days (one estrus cycle). the findings revealed that after paradoxical sleep deprivation, sleep efficiency and paradoxical sleep returned to baseline values on the second day of the light period, for all except the proestrus group. During the dark rebound period, only the female groups presented increased sleep efficiency on the first day. Paradoxical sleep returned to baseline values on the third day, except for males and the cycling females submitted to paradoxical sleep deprivation in the diestrus phase, whose baseline values returned to normal on the second day of rebound period. Thus, the females and males displayed distinct patterns as a result of sleep disruption. (C) 2008 Elsevier Inc. All rights reserved.
Keywords EEG
estrous cycle
female rats
gender
sleep deprivation
sleep rebound
Language English
Date 2008-05-15
Published in Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 32, n. 4, p. 975-983, 2008.
ISSN 0278-5846 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 975-983
Origin http://dx.doi.org/10.1016/j.pnpbp.2008.01.007
Access rights Closed access
Type Review
Web of Science ID WOS:000256570400009
URI http://repositorio.unifesp.br/handle/11600/30667

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