Bone marrow cells are able to increase vessels number during repair of sciatic nerve lesion

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dc.contributor.author Fernandes, Marcela [UNIFESP]
dc.contributor.author Valente, Sandra Gomes [UNIFESP]
dc.contributor.author Silva Fernandes, Maria Jose da [UNIFESP]
dc.contributor.author Villar Felix, Evandro Penteado [UNIFESP]
dc.contributor.author Naffah Mazzacoratti, Maria da Graca [UNIFESP]
dc.contributor.author Scerni, Debora Amado [UNIFESP]
dc.contributor.author Gomes dos Santos, Joao Baptista [UNIFESP]
dc.contributor.author Leite, Vilnei Mattioli [UNIFESP]
dc.contributor.author Faloppa, Flavio [UNIFESP]
dc.date.accessioned 2016-01-24T13:51:23Z
dc.date.available 2016-01-24T13:51:23Z
dc.date.issued 2008-05-15
dc.identifier http://dx.doi.org/10.1016/j.jneumeth.2007.12.009
dc.identifier.citation Journal of Neuroscience Methods. Amsterdam: Elsevier B.V., v. 170, n. 1, p. 16-24, 2008.
dc.identifier.issn 0165-0270
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/30665
dc.description.abstract The aim of this study was to compare the outcomes of nerve autografts (GRF) and venous grafts containing mononuclear bone marrow cells (BMCs) in sciatic nerve-lesioned rats. Control animals underwent sham operations (SHAM), received empty venous grafts (EPV), or received venous grafts containing BMC vehicle (AGR). Outcome was evaluated through sciatic functional index (SIFI), morphometric and morphologic analyses of the nerve distal to the lesion, and the number of spinal cord motor neurons positive for the retrograde tracer, Fluoro-Gold (R). All groups exhibited poor results in SFI when compared to SHAM animals throughout the postoperative period. All groups also had a significantly greater fiber density, decreased fiber diameter, and decreased motor neuron number than the SHAM group. No significant difference between the GRF and BMC groups was observed in any of these parameters. On the other hand, vessel density was significantly higher in BMC than all other groups. BMC-containing venous grafts are superior to nerve autografts in increasing vessel density during sciatic nerve regeneration. (c) 2007 Elsevier B.V. All rights reserved. en
dc.format.extent 16-24
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Journal of Neuroscience Methods
dc.rights Acesso restrito
dc.subject bone marrow cells en
dc.subject grafts en
dc.subject nerve regeneration en
dc.subject sciatic nerve en
dc.subject rats en
dc.title Bone marrow cells are able to increase vessels number during repair of sciatic nerve lesion en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Orthoped & Traumatol, BR-04038032 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Neurol & Neurosurg, BR-04023900 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Biochem, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Orthoped & Traumatol, BR-04038032 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Neurol & Neurosurg, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Biochem, BR-04023900 São Paulo, Brazil
dc.identifier.doi 10.1016/j.jneumeth.2007.12.009
dc.description.source Web of Science
dc.identifier.wos WOS:000255697400003



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