Author |
Hoexter, M. Q.
![]() ![]() Shih, M. C. ![]() ![]() Mendes, D. D. ![]() ![]() Godeiro, C. ![]() ![]() Felicio, A. C. ![]() ![]() Fu, Y. K. ![]() Tufik, S. ![]() ![]() Bressan, R. A. ![]() ![]() |
Institution | Universidade Federal de São Paulo (UNIFESP) Inst Nucl Energy Res |
Abstract | Background Kleine-Levin syndrome (KLS) is a rare disorder whose pathophysiological mechanisms remain unknown.Patients and methods To investigate dopamine abnormalities in KLS, a [Tc-99m] - TRODAT-1 single photon emission computerized tomography (SPECT) was performed in a patient with KLS during the asymptomatic period and compared with three matched healthy controls.Results the patient had 14% lower striatal dopamine transporter binding potential (DAT-BP) compared to the mean DAT-BP of three healthy controls.Conclusion This study provides in vivo evidence for abnormalities in the DAT-BP, suggesting an involvement of the dopaminergic system in the pathophysiology of KLS. |
Keywords |
dopamine transporter
Kleine-Levin syndrome single photon emission computed tomography striatum TRODAT-1 |
Language | English |
Date | 2008-05-01 |
Published in | Acta Neurologica Scandinavica. Oxford: Blackwell Publishing, v. 117, n. 5, p. 370-373, 2008. |
ISSN | 0001-6314 (Sherpa/Romeo, impact factor) |
Publisher | Blackwell Publishing |
Extent | 370-373 |
Origin |
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Access rights | Closed access |
Type | Editorial |
Web of Science ID | WOS:000254807500014 |
URI | http://repositorio.unifesp.br/handle/11600/30660 |
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