Lower dopamine transporter density in an asymptomatic patient with Kleine-Levin syndrome

Lower dopamine transporter density in an asymptomatic patient with Kleine-Levin syndrome

Author Hoexter, M. Q. Autor UNIFESP Google Scholar
Shih, M. C. Autor UNIFESP Google Scholar
Mendes, D. D. Autor UNIFESP Google Scholar
Godeiro, C. Autor UNIFESP Google Scholar
Felicio, A. C. Autor UNIFESP Google Scholar
Fu, Y. K. Google Scholar
Tufik, S. Autor UNIFESP Google Scholar
Bressan, R. A. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Inst Nucl Energy Res
Abstract Background Kleine-Levin syndrome (KLS) is a rare disorder whose pathophysiological mechanisms remain unknown.Patients and methods To investigate dopamine abnormalities in KLS, a [Tc-99m] - TRODAT-1 single photon emission computerized tomography (SPECT) was performed in a patient with KLS during the asymptomatic period and compared with three matched healthy controls.Results the patient had 14% lower striatal dopamine transporter binding potential (DAT-BP) compared to the mean DAT-BP of three healthy controls.Conclusion This study provides in vivo evidence for abnormalities in the DAT-BP, suggesting an involvement of the dopaminergic system in the pathophysiology of KLS.
Keywords dopamine transporter
Kleine-Levin syndrome
single photon emission computed tomography
striatum
TRODAT-1
Language English
Date 2008-05-01
Published in Acta Neurologica Scandinavica. Oxford: Blackwell Publishing, v. 117, n. 5, p. 370-373, 2008.
ISSN 0001-6314 (Sherpa/Romeo, impact factor)
Publisher Blackwell Publishing
Extent 370-373
Origin http://dx.doi.org/10.1111/j.1600-0404.2007.00942.x
Access rights Closed access
Type Editorial
Web of Science ID WOS:000254807500014
URI http://repositorio.unifesp.br/handle/11600/30660

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