Variant isolates of human metapneumovirus subgroup B genotype 1 in Campinas, Brazil

Variant isolates of human metapneumovirus subgroup B genotype 1 in Campinas, Brazil

Author Da Silva, Luciana Helena Antoniassi Google Scholar
Spilki, Fernando Rosado Google Scholar
Riccetto, Adriana Gut Lopes Google Scholar
Almeida, Renata Servan de Google Scholar
Baracat, Emilio Carlos Elias Google Scholar
Arns, Clarice Weis Google Scholar
Institution Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Background: Human metapneumovirus (HMPV) is a paramyxovirus associated with respiratory illness. the genotypes of HMPV isolates in Brazil have not been well characterized.Objectives: To investigate the presence of HMPV in clinical samples collected from pediatric patients of two university hospitals in the region of Campinas (São Paulo, Brazil) and to genotype them by partial sequencing of the HMPV F gene.Study design: Nasopharyngeal aspirates were collected from children hospitalized between April and September, 2004 because of acute respiratory infections (ARI).Results: We identified HMPV in 8 of 142 (5.6%) clinical samples. We determined through phylogenetic analysis that HMPV isolates in Campinas during the study were clustered within subgroup B genotype 1. Two of the isolates analyzed showed significant differences from previously isolated B I viruses, when compared to HMPV isolated in South Africa and,Canada, and clustered in a separate branch within this genotype.Conclusions: in 2004 in our geographic region all HMPV isolates from pediatric patients were in the B I HMPV genetic group, with two variant isolates. (c) 2007 Elsevier B.V. All rights reserved.
Keywords human metapneumovirus
molecular characterization
genotype B subgroup 1
Language English
Date 2008-05-01
Published in Journal of Clinical Virology. Amsterdam: Elsevier B.V., v. 42, n. 1, p. 78-81, 2008.
ISSN 1386-6532 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 78-81
Access rights Closed access
Type Article
Web of Science ID WOS:000256391600015

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