Biotechnological applications of brown spider (Loxosceles genus) venom toxins

Biotechnological applications of brown spider (Loxosceles genus) venom toxins

Author Senff-Ribeiro, Andrea Google Scholar
Silva, Paulo Henrique da Google Scholar
Chaim, Olga Meiri Autor UNIFESP Google Scholar
Gremski, Luiza Helena Autor UNIFESP Google Scholar
Paludo, Katia Sabrina Autor UNIFESP Google Scholar
Silveira, Rafael Bertoni da Google Scholar
Gremski, Waldemiro Google Scholar
Mangili, Oldemir Carlos Google Scholar
Veiga, Silvio Sanches Google Scholar
Institution Univ Fed Parana
Universidade Federal de São Paulo (UNIFESP)
Univ Estadual Ponta Grossa
Catholic Univ Parana
Abstract Loxoscelisin (the term used to define accidents by the bite of brown spiders) has been reported worldwide. Clinical manifestations following brown spider bites are frequently associated with skin degeneration, a massive inflammatory response at the injured region, intravascular hemolysis, platelet aggregation causing thrombocytopenia and renal disturbances. the mechanisms by which the venom exerts its noxious effects are currently under investigation. the whole venom is a complex mixture of toxins enriched with low molecular mass proteins in the range of 5-40 kDa. Toxins including alkaline phosphatase, hyaluronidase, metalloproteases (astacin-like proteases), low molecular mass (5.6-7.9 kDa) insecticidal peptides and phospholipases-D (dermonecrotic toxins) have been identified in the venom. the purpose of the present review is to describe biotechnological applications of whole venom or some toxins, with especial emphasis upon molecular biology findings obtained in the last years. (C) 2007 Elsevier Inc. All rights reserved.
Keywords Loxosceles
venom
toxins
recombinant toxins
brown spider
biotechnological applications
Language English
Date 2008-05-01
Published in Biotechnology Advances. Oxford: Pergamon-Elsevier B.V., v. 26, n. 3, p. 210-218, 2008.
ISSN 0734-9750 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 210-218
Origin http://dx.doi.org/10.1016/j.biotechadv.2007.12.003
Access rights Closed access
Type Review
Web of Science ID WOS:000255700600003
URI http://repositorio.unifesp.br/handle/11600/30636

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