Methylphenidate DAT binding in adolescents with Attention-Deficit/Hyperactivity Disorder comorbid with substance use disorder - a single photon emission computed tomography with [Tc-99m] TRODAT-1 study

Methylphenidate DAT binding in adolescents with Attention-Deficit/Hyperactivity Disorder comorbid with substance use disorder - a single photon emission computed tomography with [Tc-99m] TRODAT-1 study

Author Szobot, Claudia M. Google Scholar
Shih, Ming Chi Autor UNIFESP Google Scholar
Schaefer, Thais Google Scholar
Junior, Neivo Google Scholar
Hoexter, Marcelo Q. Autor UNIFESP Google Scholar
Fu, Ying Kai Google Scholar
Pechansky, Flavio Google Scholar
Bressan, Rodrigo A. Autor UNIFESP Google Scholar
Rohde, Luis A. P. Google Scholar
Institution Univ Fed Rio Grande do Sul
Univ Luterana Brasil
Universidade Federal de São Paulo (UNIFESP)
Irmandade Santa Casa Misericordia
Inst Nucl Energy Res
Abstract Background: Attention-Deficit/Hyperactivity Disorder (ADHD) is highly prevalent among adolescents with Substance Use Disorders (SUD). Effects of methylphenidate (MPH) on ADHD are attributed to its properties of blocking the dopamine transporter (DAT) in the striatum. However, it has been demonstrated that drug addiction is associated with dopaminergic system changes that may affect MPH brain effects, emphasizing the need to better understand MPH actions in subjects with ADHD+SUD. Objectives: To evaluate the effect of an extended release formulation of MPH (MPH-SODAS) on DAT availability in 17 stimulant-naive ADHD adolescents with comorbid SUD (cannabis and cocaine). Methods: Subjects underwent two single photon emission computed tomography (SPECT) scans with [Tc-99m] TRODAT-1, at baseline and after 3 weeks on MPH-SODAS. Clinical assessment for ADHD relied on the Swanson, Nolan and Pelham Scale-version IV (SNAP-IV). Caudate and putamen DAT binding potential (BP) was calculated. Results: After 3 weeks on MPH-SODAS, there was a significant reduction of SNAP-IV total scores (p<0.001), and similar to 52% reductions of DAT BP at the left and right caudate. Similar decreases were found at the left and right putamen (p<0.001 for all analyses). Discussion: This study shows that the magnitude of DAT blockade induced by MPH in this population is similar to what is found in ADHD patients without SUD comorbidity, providing neurobiological support for trials with stimulants in adolescents with ADHD+SUD, an important population excluded from studies. (C) 2008 Elsevier Inc. All rights reserved.
Keywords Attention-Deficit/Hyperactivity Disorder
substance use disorders
methylphenidate
SPECT
dopamine transporter
adolescents
Language English
Date 2008-04-15
Published in Neuroimage. San Diego: Academic Press Inc Elsevier Science, v. 40, n. 3, p. 1195-1201, 2008.
ISSN 1053-8119 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 1195-1201
Origin http://dx.doi.org/10.1016/j.neuroimage.2007.12.050
Access rights Closed access
Type Article
Web of Science ID WOS:000254728200018
URI http://repositorio.unifesp.br/handle/11600/30599

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