Optimized cutoffs improve performance of the aspartate aminotransferase to platelet ratio index for predicting significant liver fibrosis in human immunodeficiency virus/hepatitis C virus co-infection

Show simple item record

dc.contributor.author Carvalho-Filho, Roberto J. [UNIFESP]
dc.contributor.author Schiavon, Leonardo L. [UNIFESP]
dc.contributor.author Narciso-Schiavon, Janaina L. [UNIFESP]
dc.contributor.author Sampaio, Juliana P. [UNIFESP]
dc.contributor.author Lanzoni, Valeria P. [UNIFESP]
dc.contributor.author Ferraz, Maria Lucia G. [UNIFESP]
dc.contributor.author Silva, Antonio Eduardo B. [UNIFESP]
dc.date.accessioned 2016-01-24T13:49:44Z
dc.date.available 2016-01-24T13:49:44Z
dc.date.issued 2008-04-01
dc.identifier http://dx.doi.org/10.1111/j.1478-3231.2008.01675.x
dc.identifier.citation Liver International. Oxford: Blackwell Publishing, v. 28, n. 4, p. 486-493, 2008.
dc.identifier.issn 1478-3223
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/30585
dc.description.abstract Aim: To assess the diagnostic value of modified cutoffs for aspartate aminotransferase to platelet ratio index (APRI) to predict significant liver fibrosis in human immunodeficiency virus (HIV)/hepatitis C virus (HCV) patients. Methods: This retrospective cross-sectional study included consecutive patients with HIV/HCV co-infection who underwent percutaneous liver biopsy. the accuracy of APRI for the diagnosis of significant fibrosis (F2/F3/F4 METAVIR) was evaluated by estimating the positive and negative predictive values (PPV and NPV respectively) and by measuring the area under the receiver operating characteristics curve (AUROC). Results: One hundred and eleven patients were included (73% men, mean age 40.2 +/- 7.8 years). Significant fibrosis was observed in 45 patients (41%). To discriminate these subjects, the AUROC of APRI was 0.774 +/- 0.045. An APRI >= 1.8 showed a PPV of 75% for the presence of significant fibrosis, and an index < 0.6 excluded significant fibrosis with an NPV of 87%. If biopsy indication was based only on APRI and restricted to scores in the intermediate range (>= 0.6 and < 1.8), 46% of liver biopsies could have been avoided as compared with 40% using the classical cutoffs. Conclusion: APRI with adjusted cutoffs can predict significant liver fibrosis in patients with HIV/HCV co-infection and might obviate the need to perform a biopsy in a considerable percentage of those subjects. en
dc.format.extent 486-493
dc.language.iso eng
dc.publisher Blackwell Publishing
dc.relation.ispartof Liver International
dc.rights Acesso restrito
dc.subject co-infection en
dc.subject fibrosis markers en
dc.subject hepatitis C en
dc.subject HIV en
dc.subject liver fibrosis en
dc.title Optimized cutoffs improve performance of the aspartate aminotransferase to platelet ratio index for predicting significant liver fibrosis in human immunodeficiency virus/hepatitis C virus co-infection en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Hepatitis Viruses Sect, Div Gastroenterol, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Hepatitis Viruses Sect, Div Gastroenterol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Pathol, São Paulo, Brazil
dc.identifier.doi 10.1111/j.1478-3231.2008.01675.x
dc.description.source Web of Science
dc.identifier.wos WOS:000253980300010



File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search


Browse

Statistics

My Account