Diversity in Paracoccidioides brasiliensis. the PbGP43 gene as a genetic marker

Diversity in Paracoccidioides brasiliensis. the PbGP43 gene as a genetic marker

Author Puccia, Rosana Autor UNIFESP Google Scholar
McEwen, Juan G. Google Scholar
Cisalpino, Patricia Silva Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
CIB
Univ Antioquia
Universidade Federal de Minas Gerais (UFMG)
Abstract Paracoccidioides brasiliensis is a temperature-dependent dimorphic fungus and the agent of paracoccidioidomycosis (PCM), which is prevalent in rural workers of Latin American countries. Until a decade ago, most of the studies involving P. brasiliensis used clinical isolates, since environmental samples from soil are difficult to obtain. More recently, P. brasiliensis has been isolated from infected wild and domestic animals, especially from the nine-banded armadillo Dasypus novemcinctus in Brazil. Over the years, diversity within the species has been observed at several phenotypic levels. the present review will discuss the reports focusing on genetic polymorphism, which culminated with the detection of P. brasiliensis phylogenetic species as a result of a multilocus study. Polymorphism in the PbGP43 gene is detailed. This gene encodes fungal glycoprotein gp43, a dominant P. brasiliensis antigen largely studied in the last two decades for its importance in diagnosis, immune protection, and adhesive properties to extracellular matrix-associated proteins. Fungal traits associated with genetic groups are discussed.
Keywords Paracoccidioides brasiliensis
genetic polymorphism
PbGP43 gene
RAPD
chromosomal polymorphism
phylogenetic species
Language English
Date 2008-04-01
Published in Mycopathologia. Dordrecht: Springer, v. 165, n. 4-5, p. 275-287, 2008.
ISSN 0301-486X (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 275-287
Origin http://dx.doi.org/10.1007/s11046-007-9055-2
Access rights Closed access
Type Article
Web of Science ID WOS:000255256100009
URI http://repositorio.unifesp.br/handle/11600/30552

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