Annexin-A1 gene expression during liver development and post-translation modification after experimental endotoxemia

Annexin-A1 gene expression during liver development and post-translation modification after experimental endotoxemia

Author Damazo, Amilcar Sabino Autor UNIFESP Google Scholar
Flower, R. J. Google Scholar
Solito, E. Google Scholar
Oliani, S. M. Autor UNIFESP Google Scholar
Institution Universidade de São Paulo (USP)
Univ London St Bartholomews Hosp Med Coll
Univ London Imperial Coll Sci Technol & Med
Universidade Federal de São Paulo (UNIFESP)
Abstract Objective and design: We have previously reported a role for annexin-A1 in liver proliferation and tumorogenicity as well as its action as an acute phase protein in a model of endotoxemia in interleukin-6 null mice.Material and methods: in this study, we have investigated the analysis of the gene and protein expression in annexin-A1 null mice and the wild type livers during foetal and adult life, and in the presence of a proinflammatory stimulus.Results: the data indicate a link between the expression of the annexin-A1 as serine-phosphorylated-protein during early events of the inflammatory response and as tyrosine-phosphorylated-form at later time-points, during the resolution of inflammation.Conclusions: the study of annexin-A1 post-translation modification may promote a new annexin-A1 peptide discovery programme to treat specific pathologies.
Keywords hepatocytes
neutrophil
liver
inflammation
gene expression
Language English
Date 2008-03-01
Published in Inflammation Research. Basel: Birkhauser Verlag Ag, v. 57, n. 3, p. 97-103, 2008.
ISSN 1023-3830 (Sherpa/Romeo, impact factor)
Publisher Birkhauser Verlag Ag
Extent 97-103
Origin http://dx.doi.org/10.1007/s00011-007-7114-2
Access rights Closed access
Type Article
Web of Science ID WOS:000254436500002
URI http://repositorio.unifesp.br/handle/11600/30485

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