The effect of early virological response in health-related quality of life in HCV-infected patients

The effect of early virological response in health-related quality of life in HCV-infected patients

Author Quarantini, Lucas C. Autor UNIFESP Google Scholar
Miranda-Scippa, Angela Google Scholar
Batista-Neves, Susana Google Scholar
Galvao-De-Almeida, Amanda Google Scholar
Lacerda, Acioly L. Autor UNIFESP Google Scholar
Moriyama, Tais S. Autor UNIFESP Google Scholar
Sampaio, Aline S. Google Scholar
Melcop, Ana C. Autor UNIFESP Google Scholar
Schinoni, Maria I. Google Scholar
Oliveira, Irismar R. de Google Scholar
Parana, Raymundo Google Scholar
Bressan, Rodrigo A. Autor UNIFESP Google Scholar
Institution Universidade Federal da Bahia (UFBA)
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Twenty-nine HCV-infected patients were treated with pegylated interferon alpha. Diagnosis was based on serum HCV RNA-PCR positive results and liver biopsy. All patients had elevated serum levels of alanine aminotransferase at the time of the study, but liver disease was compensated. Patients were evaluated at baseline treatment and after 4 and 12 weeks of antiviral treatment with the Medical Outcomes Study 36-item Short-Form Health Survey. the Mini-International Neuropsychiatric Interview was used to exclude previous or current psychiatric diagnoses. Both patients and psychiatrists were blind to the HCV RNA status, and serum HCV RNA test results only became available after the visit at week 12. After antiviral treatment, 16 patients (55.2%) were classified as nonresponders and 13 (44.8%) were classified as responders. When compared to nonresponders, responders had a greater improvement in the HRQOL scores for the mental health domain (P<.019). Differences in other domains were not significant. the present study confirms that active viral infection is one possible reason for the poor Health-Related Quality of Life in this population.
Keywords hepatitis C
interferon alpha
quality of life
Language English
Date 2008-03-01
Published in Journal of Medical Virology. Hoboken: Wiley-liss, v. 80, n. 3, p. 419-423, 2008.
ISSN 0146-6615 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 419-423
Access rights Closed access
Type Article
Web of Science ID WOS:000252756500007

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