Circulating renin-angiotensin system and catecholamines in childhood: is there a role for birthweight?

Circulating renin-angiotensin system and catecholamines in childhood: is there a role for birthweight?

Author Franco, Maria C. P. Autor UNIFESP Google Scholar
Casarini, Dulce Elena Autor UNIFESP Google Scholar
Carneiro-Ramos, Marcella S. Google Scholar
Sawaya, Ana L. Autor UNIFESP Google Scholar
Barreto-Chaves, Maria L. M. Google Scholar
Sesso, Ricardo Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract There have been only a few reports on the sympathoadrenal and renin-angiotensin systems in children of small gestational age. the purpose of the present study was to investigate plasma levels of ACE (angiotensin-converting enzyme) activity, angiotensin and catecholamines in 8- to 13-year-old children and to determine whether there are correlations between the components of these systems with both birthweight and BP (blood pressure) levels. This clinical study included 66 children (35 boys and 31 girls) in two groups: those born at term with an appropriate birthweight [AGA (appropriate-for-gestational age) group, n = 31] and those born at term but with a small birthweight for gestational age [SGA (small-for-gestational age) group, n = 35]. Concentrations of angiotensin, catecholamines and ACE activity were determined in plasma. Circulating noradrenaline levels were significantly elevated in SGA girls compared with AGA girls (P = 0.036). in addition, angiotensin 11 and ACE activity were higher in SGA boys (P = 0.024 and P = 0.050 respectively). There was a significant association of the circulating levels of both angiotensin 11 and ACE activity with BP levels in our study population. Although the underlying mechanisms that link restricted fetal growth with later cardiovascular events are not fully understood, the findings in the present study support the link between low birthweight and overactivity of both sympathoadrenal and renin-angiotensin systems into later childhood.
Keywords angiotensin II
angiotensin-converting enzyme (ACE) activity
birthweight
blood pressure
noradrenaline
small-for-gestational age
Language English
Date 2008-03-01
Published in Clinical Science. London: Portland Press Ltd, v. 114, n. 5-6, p. 375-380, 2008.
ISSN 0143-5221 (Sherpa/Romeo, impact factor)
Publisher Portland Press Ltd
Extent 375-380
Origin http://dx.doi.org/10.1042/CS20070284
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000253849000003
URI http://repositorio.unifesp.br/handle/11600/30455

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