Cystic phaeochromocytoma is a distinctive subgroup with special clinical, imaging and histological features that might mislead the diagnosis

Cystic phaeochromocytoma is a distinctive subgroup with special clinical, imaging and histological features that might mislead the diagnosis

Author Andreoni, Cássio Autor UNIFESP Google Scholar
Krebs, Rodrigo Ketzer Autor UNIFESP Google Scholar
Bruna, Paulo C. Google Scholar
Goldman, Suzan Menasce Autor UNIFESP Google Scholar
Kater, Claudio Elias Autor UNIFESP Google Scholar
Alves, Maria Teresa de Seixas Autor UNIFESP Google Scholar
Ortiz, Valdemar Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract OBJECTIVE To report and analyse cases of cyctic phaeochromocytoma at our institution and in previous publications, as adrenal cystic masses are usually associated with nonfunctional lesions, but they can be phaeochromocytoma.PATIENTS and METHODS the prospective adrenalectomy database at our institution was reviewed to identify patients with phaeochromocytoma and cystic lesions. the clinical, radiological and histological features of cystic phaeochromocytoma were evaluated. Other previously published data were identified and compared with the present series.RESULTS in all, there were 107 adrenalectomies at our institution from November 2000 to March 2007; 31 of these patients had a confirmed diagnosis of phaeochromocytoma and six (19%) were cystic phaeochromocytomas. Three of the six cases were asymptomatic and had a negative biochemical evaluation (one male and five females, mean tumour size 6.6 cm); the imaging diagnosis was mainly based on computed tomography and magnetic resonance imaging, and the foremost feature was the enhancement of the tumour rim associated with a central cystic mass. Nine other previously published cases were reviewed.CONCLUSIONS From the present large series and previous anecdotally reported cases, patients with cystic phaeochromocytomas are more likely to be asymptomatic, to complain of chronic abdominal pain, and to have a negative biochemical evaluation, which might deter physicians from conducting a full evaluation for phaeochromocytoma and mislead the final diagnosis. As such, there could be an even higher prevalence of this entity that is yet to be determined.
Keywords adrenal
phaeochromocytoma
cysts
laparoscopy
Language English
Date 2008-02-01
Published in Bju International. Oxford: Blackwell Publishing, v. 101, n. 3, p. 345-350, 2008.
ISSN 1464-4096 (Sherpa/Romeo, impact factor)
Publisher Blackwell Publishing
Extent 345-350
Origin http://dx.doi.org/10.1111/j.1464-410X.2007.07370.x
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000252119800019
URI http://repositorio.unifesp.br/handle/11600/30395

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