Antidepressive-like effects of electroacupuncture in rats

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dc.contributor.author Santos, Jair Guilherme dos [UNIFESP]
dc.contributor.author Kawano, Fernando [UNIFESP]
dc.contributor.author Nishida, Marcio Makoto [UNIFESP]
dc.contributor.author Yamamura, Ysao [UNIFESP]
dc.contributor.author Mello, Luiz Eugenio [UNIFESP]
dc.contributor.author Tabosa, Angela [UNIFESP]
dc.date.accessioned 2016-01-24T13:49:29Z
dc.date.available 2016-01-24T13:49:29Z
dc.date.issued 2008-01-28
dc.identifier http://dx.doi.org/10.1016/j.physbeh.2007.08.014
dc.identifier.citation Physiology & Behavior. Oxford: Pergamon-Elsevier B.V., v. 93, n. 1-2, p. 155-159, 2008.
dc.identifier.issn 0031-9384
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/30379
dc.description.abstract Here, we investigate the effects of electroacupunture on the depressive-like symptoms in learned helplessness and forced swim tests in rats. Electroacupuncture stimulation (EA) was provided at ST-36 (Zusanli) and SP-6 (Sanyinjiao) acupoints. A positive control group was treated with imipramine. To verify the effects of EA over serotonergic system, other additional groups received daily, for three days, p-chlorophenylalanine and after two days, were submitted to behavioral tests. EA, like imipramine, enhanced the successful active avoidance in the learned helplessness and diminished the time spent in immobility position in the forced swim test, without affecting the number of squares crossed in the open field test. the administration of p-chlorophenylalanine abolished the antidepressive-like effect of EA. EA generates a clear antidepressant effect in two different animal models of depression, and this effect is related, at least in part, to the serotonergic system. (C) 2007 Elsevier Inc. All rights reserved. en
dc.format.extent 155-159
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Physiology & Behavior
dc.rights Acesso restrito
dc.subject electroacupuncture en
dc.subject antidepressant en
dc.subject serotonin en
dc.subject learned helplessness en
dc.subject forced swim en
dc.subject rats en
dc.title Antidepressive-like effects of electroacupuncture in rats en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Fac Ciencias Med Santa Casa
dc.description.affiliation Universidade Federal de São Paulo, Dept Physiol, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Div Chinese Med & Acupuncture, Dept Orthoped & Traumatol, São Paulo, Brazil
dc.description.affiliation Fac Ciencias Med Santa Casa, Dept Physiol Sci, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Physiol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Div Chinese Med & Acupuncture, Dept Orthoped & Traumatol, São Paulo, Brazil
dc.identifier.doi 10.1016/j.physbeh.2007.08.014
dc.description.source Web of Science
dc.identifier.wos WOS:000253034700020



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