Antidepressive-like effects of electroacupuncture in rats

Antidepressive-like effects of electroacupuncture in rats

Author Santos, Jair Guilherme dos Autor UNIFESP Google Scholar
Kawano, Fernando Autor UNIFESP Google Scholar
Nishida, Marcio Makoto Autor UNIFESP Google Scholar
Yamamura, Ysao Autor UNIFESP Google Scholar
Mello, Luiz Eugenio Autor UNIFESP Google Scholar
Tabosa, Angela Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Fac Ciencias Med Santa Casa
Abstract Here, we investigate the effects of electroacupunture on the depressive-like symptoms in learned helplessness and forced swim tests in rats. Electroacupuncture stimulation (EA) was provided at ST-36 (Zusanli) and SP-6 (Sanyinjiao) acupoints. A positive control group was treated with imipramine. To verify the effects of EA over serotonergic system, other additional groups received daily, for three days, p-chlorophenylalanine and after two days, were submitted to behavioral tests. EA, like imipramine, enhanced the successful active avoidance in the learned helplessness and diminished the time spent in immobility position in the forced swim test, without affecting the number of squares crossed in the open field test. the administration of p-chlorophenylalanine abolished the antidepressive-like effect of EA. EA generates a clear antidepressant effect in two different animal models of depression, and this effect is related, at least in part, to the serotonergic system. (C) 2007 Elsevier Inc. All rights reserved.
Keywords electroacupuncture
learned helplessness
forced swim
Language English
Date 2008-01-28
Published in Physiology & Behavior. Oxford: Pergamon-Elsevier B.V., v. 93, n. 1-2, p. 155-159, 2008.
ISSN 0031-9384 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 155-159
Access rights Closed access
Type Article
Web of Science ID WOS:000253034700020

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