Manometric study of the lower esophageal sphincter and esophagus in subtotal gastrectomy patients

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dc.contributor.author Fonseca, C. A. Marcovechio
dc.contributor.author Martinez, J. C. [UNIFESP]
dc.contributor.author Piesciotto, A.
dc.contributor.author Yanagita, E. T. [UNIFESP]
dc.contributor.author Denardin, O. V. P.
dc.contributor.author Filho, B. Herani [UNIFESP]
dc.date.accessioned 2016-01-24T13:49:26Z
dc.date.available 2016-01-24T13:49:26Z
dc.date.issued 2008-01-01
dc.identifier http://dx.doi.org/10.1111/j.1442-2050.2007.00734.x
dc.identifier.citation Diseases of the Esophagus. Oxford: Blackwell Publishing, v. 21, n. 2, p. 118-124, 2008.
dc.identifier.issn 1120-8694
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/30343
dc.description.abstract There is controversy in the literature regarding the motor function behavior of the lower esophageal sphincter and esophagus following partial gastrectomy. We studied 26 patients with gastric adenocarcinoma of the distal corpus and/or antrum who underwent radical subtotal gastrectomy with Roux-en-Y reconstruction. There were 15 women (57.69%) and 11 men (42.31%) with a mean age of 57.2 years; 21 were White (80.8%) and five were of African descent (19.2%). Before the surgery and 3 months afterwards, every patient underwent manometric and endoscopic examinations. the lower esophageal sphincter showed reductions in mean respiratory pressure (19.41-15.59 mmHg, P = 0.02) and maximum expiratory pressure (8.13-5.54 mmHg, P = 0.02) without significant alteration in diaphragmatic crura pressure (32.92-30.64 mmHg, P = 0.37). An increase in peristaltic wave amplitude (91.43-124.86 mmHg, P < 0.01) and peristaltic wave conduction velocity (3.29 cm/s to 4.23 cm/s; P = 0.024) were detected in esophageal function. the presence of erosive esophagitis decreased from 10 (38.46%) patients to none (P= 0.002). We concluded that following surgery the lower esophageal sphincter function was impaired, through decreased pressure in the esophageal component without alteration in diaphragmatic crura pressure. On the other hand, there was significant increase in peristaltic wave amplitude and velocity, and improvement of the erosive esophagitis. the authors suggest that subtotal gastrectomy, with gastroesophageal junction preservation, and Roux-en-Y reconstruction should be the preferred operation for distal gastric cancer to minimize esophageal dysfunction and gastroesophageal reflux disease. en
dc.format.extent 118-124
dc.language.iso eng
dc.publisher Blackwell Publishing
dc.relation.ispartof Diseases of the Esophagus
dc.rights Acesso restrito
dc.subject esophageal sphincter en
dc.subject gastrectomy en
dc.subject manometry en
dc.subject stomach neoplasm en
dc.title Manometric study of the lower esophageal sphincter and esophagus in subtotal gastrectomy patients en
dc.type Artigo
dc.contributor.institution Heliopolis Hosp
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Heliopolis Hosp, Dept Surg Oncol, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Surg, Digest Physiol Sector, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Surg, Endoscopy Div, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Surg, Digest Physiol Sector, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Surg, Endoscopy Div, São Paulo, Brazil
dc.identifier.doi 10.1111/j.1442-2050.2007.00734.x
dc.description.source Web of Science
dc.identifier.wos WOS:000252929600005



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