Histopathological study of 49 cases of keratoconus

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dc.contributor.author Fernandes, Bruno F.
dc.contributor.author Logan, Patrick
dc.contributor.author Zajdenweber, Moyses E.
dc.contributor.author Santos, Leonardo N.
dc.contributor.author Cheema, Devinder P.
dc.contributor.author Burnier, Miguel N. [UNIFESP]
dc.date.accessioned 2016-01-24T13:49:24Z
dc.date.available 2016-01-24T13:49:24Z
dc.date.issued 2008-01-01
dc.identifier http://dx.doi.org/10.1080/00313020802320648
dc.identifier.citation Pathology. Philadelphia: Lippincott Williams & Wilkins, v. 40, n. 6, p. 623-626, 2008.
dc.identifier.issn 0031-3025
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/30308
dc.description.abstract Aims: Keratoconus is a bilateral and asymmetrical corneal ectasia. the pathophysiology of this disorder has yet to be fully elucidated. the purpose of our study was to document the prevalence of the most common morphological features of keratoconic corneas.Methods: A retrospective analysis of 49 cases diagnosed as keratoconus between 2001 and 2006 was undertaken. Histopathological reports were reviewed to obtain data such as age and gender. Specimens were fixed in 10% buffered paraformaldehyde solution for 24h, bisected through the centre of the button, and embedded in paraffin. Sections were stained with haematoxylin and eosin (HE) and periodic acid-Schiff (PAS) for light microscopic examination.Results: the studied group was composed of 29 men and 20 women. Age at the time of the penetrating keratoplasty was 3914 years (mean +/- standard deviation). Forty of the 49 specimens (82%) presented with epithelial thinning. Other common features of keratoconus included breaks in Bowman's layer in 35 (71%), compaction of the stromal collagen fibres in 31 (63%), and folds in Descemet's membrane in 31 (63%) cases. Other less common histopathological findings were: presence of superficial iron deposits in 14 (29%), deep stromal scarring in 12 (24%), epithelial scarring in 11 (22%), endothelial cell loss in 11 (22%), and breaks in Descemet's membrane in nine (18%) cases.Conclusions: Some of the histopathological findings associated with keratoconus are subtle. It is important to be aware of them in order to properly confirm the clinical diagnosis. en
dc.format.extent 623-626
dc.language.iso eng
dc.publisher Lippincott Williams & Wilkins
dc.relation.ispartof Pathology
dc.rights Acesso restrito
dc.subject keratoconus en
dc.subject pathology en
dc.subject cornea en
dc.subject ectasia en
dc.subject transplant en
dc.title Histopathological study of 49 cases of keratoconus en
dc.type Artigo
dc.contributor.institution McGill Univ
dc.contributor.institution Henry C Witelson Ocular Pathol Lab
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation McGill Univ, Ctr Hlth, Dept Ophthalmol & Pathol, Montreal, PQ, Canada
dc.description.affiliation Henry C Witelson Ocular Pathol Lab, Montreal, PQ, Canada
dc.description.affiliation McGill Univ, Dept Ophthalmol, Ctr Hlth, Montreal, PQ H3A 2T5, Canada
dc.description.affiliation Universidade Federal de São Paulo, Dept Ophthalmol, EPM, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Ophthalmol, EPM, São Paulo, Brazil
dc.identifier.doi 10.1080/00313020802320648
dc.description.source Web of Science
dc.identifier.wos WOS:000258773900013


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