Non-alcoholic fatty liver disease in overweight children and its relationship with retinol serum levels

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dc.contributor.author Suano de Souza, Fabiola Isabel [UNIFESP]
dc.contributor.author Silverio Amancio, Olga Maria [UNIFESP]
dc.contributor.author Sarni, Roseli Oselka Saccardo [UNIFESP]
dc.contributor.author Pitta, Tassiana Sacchi
dc.contributor.author Fernandes, Ana Paula
dc.contributor.author Affonso Fonseca, Fernando Luis
dc.contributor.author Hix, Sonia
dc.contributor.author Ramalho, Rejane Andrea
dc.date.accessioned 2016-01-24T13:49:24Z
dc.date.available 2016-01-24T13:49:24Z
dc.date.issued 2008-01-01
dc.identifier http://dx.doi.org/10.1024/0300-9831.78.1.27
dc.identifier.citation International Journal for Vitamin and Nutrition Research. Bern 9: Verlag Hans Huber, v. 78, n. 1, p. 27-32, 2008.
dc.identifier.issn 0300-9831
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/30301
dc.description.abstract Objectives: To evaluate the frequency of non-alcoholic fatty liver disease, the retinol serum levels, lipid profile, and insulin resistance in overweight/obese children. To relate these biochemical variables with the risk of this disease in the population studied.Methods: the study was cross-sectional and prospective, with 46 overweight/obese school children (28 female, 18 male; mean age 8.6 years). the control group consisted of 45 children, paired by age and gender. Hepatic steatosis, evaluated by ultrasound, was classified as normal, mild, moderate, or severe. Also evaluated were serum retinol levels; thiobarbituric acid reactive substances; lipid profile; and fasting glucose and serum insulin levels, used for the calculation of the Homeostasis Model Assessment.Results: Hepatic ultrasound alterations were found in 56.5% and 48,9% of the overweight/obese and control group children, respectively. Presence of obesity was associated with-high levels of triglycerides (OR = 4.6; P 0.002). in the studied children, the risk of steatosis was related to a trend to a higher percentage of retinol inadequacy (OR = 2.8; p = 0.051); there was no association with thiobarbituric acid reactive substances, lipid profile, or insulin resistance.Conclusions: the high frequency of non-alcoholic fatty liver disease in both groups, evaluated by hepatic ultrasound, in low-socioeconomic level children, independent of nutritional condition and without significant association with insulin resistance, emphasizes that especially-in-developing countries, other risk factors such as micronutrient deficiencies (e.g. vitamin A) are involved. en
dc.format.extent 27-32
dc.language.iso eng
dc.publisher Verlag Hans Huber
dc.relation.ispartof International Journal for Vitamin and Nutrition Research
dc.rights Acesso restrito
dc.subject fatty liver en
dc.subject retiuol en
dc.subject oxidative stress en
dc.subject children en
dc.subject obesity en
dc.title Non-alcoholic fatty liver disease in overweight children and its relationship with retinol serum levels en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution ABC Sch Med
dc.contributor.institution Universidade Federal do Rio de Janeiro (UFRJ)
dc.description.affiliation Universidade Federal de São Paulo, Paulista Sch Med, Dept Pediat, BR-04023062 São Paulo, Brazil
dc.description.affiliation ABC Sch Med, Dept Pediat, Santo Andre, SP, Brazil
dc.description.affiliation Univ Fed Rio de Janeiro, Dept Nutr, BR-21941 Rio de Janeiro, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Paulista Sch Med, Dept Pediat, BR-04023062 São Paulo, Brazil
dc.identifier.doi 10.1024/0300-9831.78.1.27
dc.description.source Web of Science
dc.identifier.wos WOS:000258381100005



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