Hibernating mammals in sudden cardiac death in epilepsy: What do they tell us?

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dc.contributor.author Colugnati, Diego Basile [UNIFESP]
dc.contributor.author Arida, Ricardo M. [UNIFESP]
dc.contributor.author Cravo, Sergio L. [UNIFESP]
dc.contributor.author Schoorlemmer, Gerhardus Hermanus Maria [UNIFESP]
dc.contributor.author Almeida, Antonio-Carlos Guimaraes de
dc.contributor.author Cavalheiro, Esper a. [UNIFESP]
dc.contributor.author Scorza, Fulvio A. [UNIFESP]
dc.date.accessioned 2016-01-24T13:49:23Z
dc.date.available 2016-01-24T13:49:23Z
dc.date.issued 2008-01-01
dc.identifier http://dx.doi.org/10.1016/j.mehy.2007.10.005
dc.identifier.citation Medical Hypotheses. Edinburgh: Churchill Livingstone, v. 70, n. 5, p. 929-932, 2008.
dc.identifier.issn 0306-9877
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/30288
dc.description.abstract Epilepsy is the most common neurological disorder; approximately 1% of the population worldwide have epilepsy. Moreover, sudden unexpected death in epilepsy (SUDEP) is the most important direct epilepsy-related cause of death. Information concerning risk factors for SUDEP is conflicting, but potential risk factors include: age, early onset of epilepsy, duration of epilepsy, uncontrolled seizures, seizure frequency and AED number. Additionally, the cause of SUDEP is still unknown; however, the most commonly suggested mechanisms are cardiac abnormalities during and between seizures. Very recently, our research group was the first to annunciate that winter temperatures may lead a cardiac abnormalities and hence sudden death, become a new potential risk factor to SUDEP. Quite interesting, several mammalian species have evolved to develop a physiological phenomenon called hibernation as a strategy for survival under adverse cold conditions. From cardiovascular point of view, it has been established that hibernating mammals inherited a stable cardiovascular function as a result of adaptation to extreme external and internal environments during hibernation. for instance, hibernating mammals show resistance to hypothermia at a cellular level, the membrane potentials and excitability are more stable in the cardiac cells of these animals (action potentials (60 mV) have been recorded in hibernators myocardium at -5 degrees C), the aortic smooth muscle cells from hibernators are able to maintain ionic gradients upon prolonged exposure to low temperatures, and cardiac myocytes from hibernating mammals maintain constant levels of intracellular free calcium and forceful contractility at 10 degrees C or lower. Taken together, in this paper we postulate that hibernators have some cardiovascular particularities that confer heart protection that could positively influence the cardiovascular system of patients with epilepsy. (C) 2007 Elsevier B.V. All rights reserved. en
dc.format.extent 929-932
dc.language.iso eng
dc.publisher Churchill Livingstone
dc.relation.ispartof Medical Hypotheses
dc.rights Acesso restrito
dc.title Hibernating mammals in sudden cardiac death in epilepsy: What do they tell us? en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Univ Fedao Joao Del Rei
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Disciplina Neurol Expt, BR-04023900 São Paulo, SP, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Dept Fisiol, São Paulo, Brazil
dc.description.affiliation Univ Fedao Joao Del Rei, Dept Biomed Engn, Minas Gerais, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Disciplina Neurol Expt, BR-04023900 São Paulo, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Dept Fisiol, São Paulo, Brazil
dc.identifier.doi 10.1016/j.mehy.2007.10.005
dc.description.source Web of Science
dc.identifier.wos WOS:000255450800005



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