The regular arrangement of collecting venules pattern evaluated by standard endoscope and the absence of antrum nodularity are highly indicative of Helicobacter pylori uninfected gastric mucosa

The regular arrangement of collecting venules pattern evaluated by standard endoscope and the absence of antrum nodularity are highly indicative of Helicobacter pylori uninfected gastric mucosa

Author Machado, R. S. Autor UNIFESP Google Scholar
Viriato, A. Google Scholar
Kawakami, E. Autor UNIFESP Google Scholar
Patricio, F. R. S. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Hosp Infantil Candido Fontoura
Abstract Aim. To evaluate the accuracy of antrum nodularity and the regular arrangement of collecting venules for diagnosing Helicobacter pylori gastritis.Methods. Ninety-nine consecutive children and adolescents (1.07 years-17.69 years, mean +/- S.D. = 9.71 +/- 3.80 FM 54:45) undergoing upper digestive endoscopy were assessed for the presence of antrum nodularity and regular arrangement of collecting venules pattern to determine the status of H. pylori infection. Antrum nodularity was observed by a tangential view of the greater curvature of the gastric antrum. Regular arrangement of collecting venules was visualized as being the regular pattern of red points evaluated with a standard endoscope. Two biopsies from the antrum were collected for histology and rapid urease test. the accuracy of diagnosis based on antrum nodularity and regular arrangement of collecting venules was evaluated considering the sensitivity, specificity and likelihood ratio.Results. H. pylori was detected in 32/99 patients (32.3%). Antrum nodularity provided 59.4% sensitivity (95% confidence interval 50.7-68.1) 98.5% specificity (95% confidence interval: 97-100), likelihood ratio+ 39.78, and likelihood ratio- 0.41. A regular arrangement of collecting venules pattern provided 96.9% sensitivity (95% confidence interval: 93.8-100), 88.1% specificity (95% confidence interval: 84.1-92), likelihood ratio+ 8.11, and likelihood ratio- 0.04.Conclusion. Antrum nodularity is a specific finding, although its sensitivity is low. A regular arrangement of collecting venules pattern and the absence of antrum nodularity are highly indicative of normal gastric mucosa that is negative for Helicobacter pylori. (c) 2007 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier B.V. All rights reserved.
Keywords antrum nodularity
diagnose
digestive endoscopy
gastritis
gastric mucosa
Helicobacter pylori
Language English
Date 2008-01-01
Published in Digestive and Liver Disease. Pisa: Pacini Editore, v. 40, n. 1, p. 68-72, 2008.
ISSN 1590-8658 (Sherpa/Romeo, impact factor)
Publisher Pacini Editore
Extent 68-72
Origin http://dx.doi.org/10.1016/j.dld.2007.08.003
Access rights Closed access
Type Article
Web of Science ID WOS:000253119100011
URI http://repositorio.unifesp.br/handle/11600/30280

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