Effects of Pre or Posttraining Dorsal Hippocampus D-AP5 Injection on Fear Conditioning to Tone, Background, and Foreground Context

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dc.contributor.author Schenberg, Eduardo Ekman [UNIFESP]
dc.contributor.author Menezes Oliveira, Maria Gabriela [UNIFESP]
dc.date.accessioned 2016-01-24T13:49:21Z
dc.date.available 2016-01-24T13:49:21Z
dc.date.issued 2008-01-01
dc.identifier http://dx.doi.org/10.1002/hipo.20475
dc.identifier.citation Hippocampus. Hoboken: Wiley-liss, v. 18, n. 11, p. 1089-1093, 2008.
dc.identifier.issn 1050-9631
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/30262
dc.description.abstract NMDA receptor antagonist D-AP5 was injected into the dorsal hippocampus of Wistar rats before or immediately after the training session in fear conditioning. Training was conducted both with signaled (background context) or unsignaled (foreground context) footshocks. Contextual fear conditioning was assessed 24 h later and tone fear conditioning 48 h after training (only in the signaled footshock condition). Pretraining injections impaired conditioned fear to contextual features, both in background and foreground configurations, whereas tone fear conditioning was left intact. Posttraining injections were ineffective in all cases. We conclude that dorsal hippocampal NMDA receptors are required for contextual fear acquisition independently of context saliency and that they are not required to early consolidation processes. (C) 2008 Wiley-Liss, Inc. en
dc.format.extent 1089-1093
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Hippocampus
dc.rights Acesso restrito
dc.subject hippocampus en
dc.subject fear conditioning en
dc.subject AP5 en
dc.subject NMDA receptors en
dc.subject memory en
dc.title Effects of Pre or Posttraining Dorsal Hippocampus D-AP5 Injection on Fear Conditioning to Tone, Background, and Foreground Context en
dc.type Artigo
dc.rights.license http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.identifier.doi 10.1002/hipo.20475
dc.description.source Web of Science
dc.identifier.wos WOS:000260914000002



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