Effects of Pre or Posttraining Dorsal Hippocampus D-AP5 Injection on Fear Conditioning to Tone, Background, and Foreground Context

Effects of Pre or Posttraining Dorsal Hippocampus D-AP5 Injection on Fear Conditioning to Tone, Background, and Foreground Context

Author Schenberg, Eduardo Ekman Autor UNIFESP Google Scholar
Menezes Oliveira, Maria Gabriela Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract NMDA receptor antagonist D-AP5 was injected into the dorsal hippocampus of Wistar rats before or immediately after the training session in fear conditioning. Training was conducted both with signaled (background context) or unsignaled (foreground context) footshocks. Contextual fear conditioning was assessed 24 h later and tone fear conditioning 48 h after training (only in the signaled footshock condition). Pretraining injections impaired conditioned fear to contextual features, both in background and foreground configurations, whereas tone fear conditioning was left intact. Posttraining injections were ineffective in all cases. We conclude that dorsal hippocampal NMDA receptors are required for contextual fear acquisition independently of context saliency and that they are not required to early consolidation processes. (C) 2008 Wiley-Liss, Inc.
Keywords hippocampus
fear conditioning
AP5
NMDA receptors
memory
Language English
Date 2008-01-01
Published in Hippocampus. Hoboken: Wiley-liss, v. 18, n. 11, p. 1089-1093, 2008.
ISSN 1050-9631 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 1089-1093
Origin http://dx.doi.org/10.1002/hipo.20475
Access rights Closed access
Type Article
Web of Science ID WOS:000260914000002
URI http://repositorio.unifesp.br/handle/11600/30262

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