Change in hepatitis C virus genotype in hemodialysis patients after end-of-treatment response to interferon monotherapy-relapse or re-infection?

Change in hepatitis C virus genotype in hemodialysis patients after end-of-treatment response to interferon monotherapy-relapse or re-infection?

Author Arrais, Teresa Cristina de Oliveira Maia Autor UNIFESP Google Scholar
Van Dooren, Sonia Google Scholar
Vandamme, Anne-Mieke Google Scholar
Brechot, Christian Google Scholar
Rimlinger, Francois Google Scholar
Silva, Antonio Eduardo Benedito Autor UNIFESP Google Scholar
Perez, Renata de Mello Autor UNIFESP Google Scholar
Ferraz, Maria Lucia Cardoso Gomes Autor UNIFESP Google Scholar
Thiers, Valerie Google Scholar
Institution Erasmus MC
Universidade Federal de São Paulo (UNIFESP)
Katholieke Univ Leuven
Inst Pasteur
INSERM
Univ Paris Sud
Abstract Hepatitis C virus (HCV) infection remains common among hemodialysis patients and its occurrence is related mainly to nosocomial spread. Although dialysis patients with HCV infection respond well to interferon-based therapy, relapse is frequent. This study aimed at a selected group of hemodialysis patients infected with HCV infection undergoing interferon therapy who achieved end-of-treatment virological response but became HCV-RNA positive again 6 months after end-of-treatment. It was evaluated whether de novo HCV-RNA positivity in these non-sustained responders occurred due to lack of clearance of HCV after the initial response to interferon-alpha (relapse) or due to re-infection with a new strain (re-infection). Genotyping by Inno-LiPA and by phylogenetic tree analysis using partial HCV-NS5B sequences at two evaluation points: pre-treatment (TO) and 6 months after end-of-treatment (T0). Non-sustained responders (n = 15) carried subtypes la (8 patients), 1b (4 patients), 3a (2 patients), and 4a (11 patient) before treatment. Identical subtypes were detected in 10 patients at T18. Five patients changed genotypes at T18, suggesting nosocomial re-infection. This study emphasizes the importance of epidemiologic measures to control the re-exposure of hemodialysis patients treated previously for HCV infection.
Keywords HCV
hemodialysis
nosocomial transmission
genotype
NS5B region
Language English
Date 2008-01-01
Published in Journal of Medical Virology. Hoboken: Wiley-liss, v. 80, n. 1, p. 80-86, 2008.
ISSN 0146-6615 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 80-86
Origin http://dx.doi.org/10.1002/jmv.21050
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000251335900011
URI http://repositorio.unifesp.br/handle/11600/30223

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