Tolerogenic property of B-1b cells in a model of allergic reaction

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dc.contributor.author De Lorenzo, Beatriz. H. P. [UNIFESP]
dc.contributor.author Brito, Ronni R. N. [UNIFESP]
dc.contributor.author Godoy, Luiz Claudio
dc.contributor.author Lopes, Jose Daniel [UNIFESP]
dc.contributor.author Mariano, Mario [UNIFESP]
dc.date.accessioned 2016-01-24T13:49:17Z
dc.date.available 2016-01-24T13:49:17Z
dc.date.issued 2007-12-15
dc.identifier http://dx.doi.org/10.1016/j.imlet.2007.09.013
dc.identifier.citation Immunology Letters. Amsterdam: Elsevier B.V., v. 114, n. 2, p. 110-118, 2007.
dc.identifier.issn 0165-2478
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/30212
dc.description.abstract Since B-1 cells were first described, their origin and function remain controversial. Given the ability to produce natural antibodies and large amounts of IL-10, there is a consensus about their role in innate immunity. More recently, however, B-1 cells have been associated to adaptive immunity as well, due to the demonstration of immunological memory and antigen presentation capability. Here we demonstrate that adoptive transfer of pre-sensitized B-1b cells (obtained from OVA-sensitized mice) to naive B-1 deficient animals, drastically affects the ability of transplanted animals to mount an adaptive response upon immunization with OVA. in contrast to naive B-1 populated mice, mice transplanted with sensitized B-1 exhibit lower anti-OVA antibody levels, milder footpad swelling in response to OVA subcutaneous injection and reduced granulomatous reaction to OVA-coated beads. Moreover, we show that these pre-sensitized B-1 cells, when acting as APCs, induce poor T cell proliferation in vitro when compared with macrophages or B-1 cells obtained from naive mice. This property may be due in part to insufficient expression of the co-stimulatory molecule CD86, necessary for optimal antigen presentation. in conclusion, our data suggest a novel role for B-1 cells as part of suppressor mechanisms in the immune system. (c) 2007 Elsevier B.V. All rights reserved. en
dc.format.extent 110-118
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Immunology Letters
dc.rights Acesso restrito
dc.subject B cells en
dc.subject tolerance en
dc.subject supression en
dc.subject anergy en
dc.subject allergy en
dc.title Tolerogenic property of B-1b cells in a model of allergic reaction en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Univ Massachusetts
dc.description.affiliation Universidade Federal de São Paulo, Discipline Immunol, Dept Microbiol Immunol & Parasitol, São Paulo, Brazil
dc.description.affiliation Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Discipline Immunol, Dept Microbiol Immunol & Parasitol, São Paulo, Brazil
dc.identifier.doi 10.1016/j.imlet.2007.09.013
dc.description.source Web of Science
dc.identifier.wos WOS:000252164600008



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