Tolerogenic property of B-1b cells in a model of allergic reaction

Tolerogenic property of B-1b cells in a model of allergic reaction

Author De Lorenzo, Beatriz. H. P. Autor UNIFESP Google Scholar
Brito, Ronni R. N. Autor UNIFESP Google Scholar
Godoy, Luiz Claudio Google Scholar
Lopes, Jose Daniel Autor UNIFESP Google Scholar
Mariano, Mario Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Massachusetts
Abstract Since B-1 cells were first described, their origin and function remain controversial. Given the ability to produce natural antibodies and large amounts of IL-10, there is a consensus about their role in innate immunity. More recently, however, B-1 cells have been associated to adaptive immunity as well, due to the demonstration of immunological memory and antigen presentation capability. Here we demonstrate that adoptive transfer of pre-sensitized B-1b cells (obtained from OVA-sensitized mice) to naive B-1 deficient animals, drastically affects the ability of transplanted animals to mount an adaptive response upon immunization with OVA. in contrast to naive B-1 populated mice, mice transplanted with sensitized B-1 exhibit lower anti-OVA antibody levels, milder footpad swelling in response to OVA subcutaneous injection and reduced granulomatous reaction to OVA-coated beads. Moreover, we show that these pre-sensitized B-1 cells, when acting as APCs, induce poor T cell proliferation in vitro when compared with macrophages or B-1 cells obtained from naive mice. This property may be due in part to insufficient expression of the co-stimulatory molecule CD86, necessary for optimal antigen presentation. in conclusion, our data suggest a novel role for B-1 cells as part of suppressor mechanisms in the immune system. (c) 2007 Elsevier B.V. All rights reserved.
Keywords B cells
tolerance
supression
anergy
allergy
Language English
Date 2007-12-15
Published in Immunology Letters. Amsterdam: Elsevier B.V., v. 114, n. 2, p. 110-118, 2007.
ISSN 0165-2478 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 110-118
Origin http://dx.doi.org/10.1016/j.imlet.2007.09.013
Access rights Closed access
Type Article
Web of Science ID WOS:000252164600008
URI http://repositorio.unifesp.br/handle/11600/30212

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