A possible anti-proliferative and anti-metastatic effect of irradiated riboflavin in solid tumours

A possible anti-proliferative and anti-metastatic effect of irradiated riboflavin in solid tumours

Author Souza Queiroz, Karla Cristiana de Google Scholar
Zambuzzi, Willian Fernando Google Scholar
Souza, Ana Carolina Santos de Google Scholar
Silva, Rodrigo Augusto da Google Scholar
Machado, Daisy Google Scholar
Justo, Giselle Zenker Google Scholar
Carvalho, Hernandes F. Google Scholar
Peppelenbosch, Maikel P. Google Scholar
Ferreira, Carmen Verissima Google Scholar
Institution Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de São Paulo (UNIFESP)
Univ Groningen
Abstract Riboflavin is a potent photosensitizer as well as part of the vitamin B complex. Recently we demonstrated that the products generated by irradiation of riboflavin have potential as anti-leukaemic therapy. the possible action, however, of the riboflavin photoproducts in solid cancers has not been addressed. Hence, we investigated the effects of irradiated riboflavin on androgen-independent human prostate cancer cells (PC3), a known model for solid tumour cells with an exceptional resistance to therapy. Our results show that riboflavin photoproducts are cytotoxic to these cells in a FasL-Fas-dependent manner. Furthermore, irradiated riboflavin inhibited matrix-degrading proteases, caused downregulation of VEGF and upregulation of TIMP1 suggesting anti-metastatic potential. Together, these results show that the anti-neoplastic action of riboflavin photoproducts is not limited to haematological malignancies, warranting clinical studies in solid tumours. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
Keywords prostate cancer
riboflavin
apoptosis
Language English
Date 2007-12-08
Published in Cancer Letters. Clare: Elsevier B.V., v. 258, n. 1, p. 126-134, 2007.
ISSN 0304-3835 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 126-134
Origin http://dx.doi.org/10.1016/j.canlet.2007.08.024
Access rights Closed access
Type Article
Web of Science ID WOS:000251407200015
URI http://repositorio.unifesp.br/handle/11600/30208

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